In vitro cholinesterase enzymes inhibitory potential and in silico molecular docking studies of biogenic metal oxides nanoparticles

The inhibition of Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzymes represents a potential target in the treatment of Alzheimer disease. AChE and BChE inhibition was studied by biogenic metal oxide nanoparticles (ZnO, NiO, Fe 2 O 3 , Co 3 O 4 and PbO) synthesized using aqueous extracts of Sageretia thea (Osbeck.). The results demonstrated that the highest inhibition was shown by PbO nanoparticles with the IC50 values of 101.9 µg/mL for AChE and 119.8 µg/mL for BChE. Furthermore, the results obtained from molecular docking studies analyzing the interaction of nanoparticles with enzymes, were in good agreement with the experimental data.