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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Treatment of operable breast cancer in the elderly: A randomised clinical trial EORTC 10850 comparing modified radical mastectomy with tumorectomy plus tamoxifen
European Journal of Cancer, Volume 39, No. 3, Year 2003
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Description
We have examined the outcome of older patients with operable breast cancer treated in a randomised trial by either standard surgery or less extensive surgery and tamoxifen. There were 236 participants aged ≥70 years, randomised to either modified radical mastectomy MRM (n=120) or wide local excision (WLE) and tamoxifen (T) 20 mg daily (n=116). Survival curves were estimated using the Kaplan-Meier method and multivariate analyses were performed using Cox's proportional hazards model. Endpoints were survival and time to first relapse or progression, loco-regional progression, time to distant progression and progression-free survival. No significant difference was seen in terms of progression-free survival, but there were significantly more loco-regional relapses in the WLE+T group. In contrast, there were more distant metastases in the MRM group, but with a similar overall survival in both groups. The results of this trial give cautious support for the use of WLE+T for selected older women. © 2003 Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Fentiman, Ian Stuart
United Kingdom, London
Guy's Hospital
van Zijl, Jacobus A.
South Africa, Tygerberg
Tygerberg Hospital
Karydas, Irini
Greece, Athens
Saint Savvas Hospital
Chaudary, Murid A.
United Kingdom, London
Guy's Hospital
Margreiter, Raimund
Austria, Innsbruck
Landeskrankenhaus Innsbruck
Legrand, Catherine C.
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Therasse, Patrick
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Statistics
Citations: 7
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/S0959-8049(02)00672-X
ISSN:
09598049
Research Areas
Cancer
Health System And Policy
Participants Gender
Female