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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Treatment of cervicitis is associated with decreased cervical shedding of HIV-1
AIDS, Volume 15, No. 1, Year 2001
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Description
Objective: To determine whether cervical mucosal shedding of HIV-1 RNA and HIV-1 infected cells decreases following successful treatment of cervicitis. Design: Prospective interventional study. Setting: Sexually Transmitted Infections Clinic, Coast Provincial General Hospital, Mombasa, Kenya. Participants: Thirty-six HIV-1 seropositive women with cervicitis: 16 with Neisseria gonorrhoeae, seven with Chlamydia trachomatis, and 13 with non-specific cervicitis. interventions: Treatment of cervicitis. Main outcome measures: Levels of total (cell-free and cell-associated) HIV-1 RNA and presence of HIV-1 DNA (a marker for infected cells) in cervical secretions before and after resolution of cervicitis. Results: After treatment of cervicitis, the median HIV-1 RNA concentration in cervical secretions was reduced from 4.05 to 3.24 log10 copies/swab (P = 0.001). Significant decreases in cervical HIV-1 RNA occurred in the subgroups with N. gonorrhoeae (3.94 to 3.28 log10 copies/swab; P = 0.02) and C. trachomatis (4.21 to 3.19 log10 copies/swab; P = 0.02). Overall, the prevalence of HIV-1 infected cells in cervical secretions also decreased after treatment, from 67% to 42% (odds ratio, 2.8; 95% confidence interval, 1.3-6.0; P = 0.009). Detection of infected cells was associated with higher mean HIV-1 RNA levels (4.04 versus 2.99 log10 copies/swab; P < 0.0001). Conclusions: Effective treatment of cervicitis resulted in significant decreases in shedding of HIV-1 virus and infected cells in cervical secretions. Treatment of sexually transmitted diseases may be an important means of decreasing the infectivity of HIV-1 seropositive women by reducing exposure to HIV-1 in genital secretions. © 2001 Lippincott Williams & Wilkins.
Authors & Co-Authors
McClelland, Raymond Scott
United States, Seattle
University of Washington
Wang, Chia C.
United States, Seattle
University of Washington
Mandaliya, Kishor N.
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Overbaugh, Julie M.
United States, Seattle
University of Washington
Reiner, Maureen T.
United States, Seattle
University of Washington
Panteleeff, Dana De Vange
United States, Seattle
University of Washington
Lavreys, Ludo
United States, Seattle
University of Washington
Ndinya-Achola, Jeckoniah O.
Kenya, Nairobi
University of Nairobi
Bwayo, Job J.
Kenya, Nairobi
University of Nairobi
Kreiss, Joan K.
United States, Seattle
University of Washington
Statistics
Citations: 198
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1097/00002030-200101050-00015
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Locations
Kenya
Participants Gender
Female