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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Rapidly Boosted Plasma IL-5 Induced by Treatment of Human Schistosomiasis haematobium Is Dependent on Antigen Dose, IgE and Eosinophils
PLoS Neglected Tropical Diseases, Volume 7, No. 3, Article e2149, Year 2013
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Description
Background: IgE specific to worm antigen (SWA) and pre-treatment eosinophil number, are associated with human immunity to re-infection with schistosomes after chemotherapeutic treatment. Treatment significantly elevates circulating IL-5 24-hr post-treatment of Schistosoma mansoni. Here we investigate if praziquantel treatment of human schistosomiasis haematobium also boosts circulating IL-5, the immunological and parasitological factors that predispose to this, and the relationship between these and subsequent immunity to post-treatment re-infection. Methodology/Principle Findings: The relationship between pre-treatment SWA-IgE, eosinophil number and infection intensity and the 24-hr post-treatment IL-5 boost was investigated in a Malian cohort (aged 5-40 yrs), exposed to S. haematobium. Eotaxin levels were measured at 24-hr post-treatment as a proxy of eosinophil migration. The relationship between the 24-hr post-treatment IL-5 boost and later eosinophil numbers and SWA-IgE levels (9-wk post-treatment) was examined, then investigated in the context of subsequent levels of re-infection (2-yr post-treatment). Circulating IL-5 levels increased 24-hr post-treatment and were associated with pre-treatment infection intensity, SWA-IgE levels, eosinophil number, as well as 24-hr post-treatment eotaxin levels. 24-hr IL-5 levels were, in turn, significantly associated with eosinophil number and elevated SWA-IgE 9-wk later. These SWA-IgE levels were significantly associated with immunity to re-infection. Conclusions/Significance: Early IL-5 production after treatment-induced exposure to S. haematobium worm antigen is positively associated with antigen dose (infection intensity), IgE availability for arming of effector cells at time of treatment and subsequent eosinophil migration response (as indicated by eotaxin levels). The IL-5 produced is positively associated with increased downstream eosinophil number and increases in specific IgE levels, implicating this cytokine boost and its down-stream consequences in the production and maintenance of IgE, and subsequent re-infection immunity. © 2013 Wilson et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3610616/bin/pntd.0002149.s001.doc
Authors & Co-Authors
Wilson, Shona
United Kingdom, Cambridge
University of Cambridge
Jones, Frances M.
United Kingdom, Cambridge
University of Cambridge
Fofana, H. K.M.
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Doucouré, Aïssata
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Landouré, Aly
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Kimani, Gachuhi G.
Kenya, Nairobi
Kenya Medical Research Institute
Mwatha, Joseph K.
Kenya, Nairobi
Kenya Medical Research Institute
Sacko, Moussa
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Vennervald, Birgitte Jyding
Denmark, Copenhagen
Dbl -center for Health Research and Development
Dunne, David William
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 14
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pntd.0002149
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Infectious Diseases
Study Design
Cohort Study