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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Field evaluation of FD-DAT, rK39 dipstick and KATEX (urine latex agglutination) for diagnosis of visceral leishmaniasis in northwest Ethiopia
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 101, No. 9, Year 2007
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Description
Three novel diagnostic tests for visceral leishmaniasis (VL), namely FD-DAT, rK39 dipstick and KATEX, were evaluated under field conditions using 101 clinical cases suspected of having VL enrolled in a trial either by active (63 patients) or passive (38 patients) surveillance. VL was confirmed in 49 patients: 35 by both aspirate smear microscopy and NNN culture, 10 by NNN culture alone and 4 by aspirate smear microscopy alone. Based on tests performed in the field, sensitivity for FD-DAT, rK39 dipstick and KATEX was determined to be 95.3% (95% CI 82.9-99.2%), 71.7% (95% CI 56.3-83.5%) and 57.4% (95% CI 42.3-71.4%), respectively. Similarly, the specificity was determined to be 62.7% (95% CI 48.1-75.5%), 82.4% (95% CI 68.6-91.1%) and 84.3% (95% CI 70.9-92.5%), respectively. A higher sensitivity of KATEX (73.9% vs. 41.7%) and higher specificity of FD-DAT (100.0% vs. 48.6%) were demonstrated under passive case detection compared with active case detection. FD-DAT is recommended for confirmation of VL diagnosis in hospital settings, whereas its use in the field will be limited to exclude VL in clinical suspects. The sensitivity of KATEX and rK39 dipstick tests needs to be improved to promote their use as first-line diagnostic tests in the field setting of northwestern Ethiopia. © 2007 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Diro, Ermias
Ethiopia, Gondar
University of Gondar
Techane, Yoseph
Ethiopia
Kahsay Abera Hospital
Tefera, Tewodros
Ethiopia
Kahsay Abera Hospital
Assefa, Yibeltal Alemu
Ethiopia
Kahsay Abera Hospital
Kebede, Tadesse
Ethiopia, Addis Ababa
School of Medicine
Genetu, Abebe
Ethiopia, Gondar
University of Gondar
Kebede, Yenew
Ethiopia, Gondar
University of Gondar
Tesfaye, Abiye
Ethiopia, Gondar
University of Gondar
Ergicho, Bahiru
Ethiopia, Gondar
University of Gondar
Gebre-Yohannes, Asfawesen
Ethiopia, Gondar
University of Gondar
Mengistu, Getahun
Ethiopia, Gondar
University of Gondar
Engers, Howard D.
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Aseffa, Abraham
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Desjeux, Philippe M.P.
Switzerland, Geneva
Organisation Mondiale de la Santé
Boelaert, Marleen C.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Hailu, Asrat
Ethiopia, Addis Ababa
School of Medicine
Statistics
Citations: 65
Authors: 16
Affiliations: 6
Identifiers
Doi:
10.1016/j.trstmh.2007.05.002
ISSN:
00359203
Research Areas
Health System And Policy
Study Locations
Ethiopia