A BODIPY-based 'turn-on' fluorescent probe for hypoxic cell imaging
Chemical Communications, Volume 51, No. 69, Year 2015
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A boron-dipyrromethene (BODIPY) dye containing a styryl substituent with a hydroxyl and nitro group, 1a, exhibits a 'turn-on' fluorescence response for hypoxic cells. The presence of the electron-withdrawing nitro group results in a highly efficient nonradiative decay of the S1 state, and hence a recovery of fluorescence intensity when nitro reduction occurs under hypoxic conditions.