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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
International development of an EORTC questionnaire for assessing health-related quality of life in chronic myeloid leukemia patients: The EORTC QLQ-CML24
Quality of Life Research, Volume 23, No. 3, Year 2014
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Description
Background: Health-related quality of life (HRQOL) is a key aspect for chronic myeloid leukemia (CML) patients. The aim of this study was to develop a disease-specific HRQOL questionnaire for patients with CML to supplement the European Organization for Research and Treatment of Cancer (EORTC)-QLQ C30. Patients and methods: The process followed a predefined and systematic stepwise iterative process as defined by the EORTC guidelines for questionnaire development. The process was divided into 3 phases: (1) generation of relevant HRQOL issues, (2) operationalization of the HRQOL issues into a set of items, and (3) pretesting the questionnaire for relevance and acceptability. Descriptive statistics and psychometric analyses were also performed. Results: Overall, 655 CML patients were enrolled in 10 countries including the USA and countries in Europe and Asia. Interviews with health-care professionals experienced in CML (n = 59) were also conducted. Results from the interviews, clinical experiences, and statistical analyses were used to develop the EORTC QLQ-CML24. The final module consists of 24 items assessing the following aspects: symptom burden, impact on daily life and on worry/mood, body image problems, and satisfaction with care and with social life. Internal consistency, assessed with Cronbach's alpha coefficients, ranged from 0.73 to 0.83 for the proposed scales. Conclusion: The EORTC QLQ-CML24 is an internationally developed HRQOL questionnaire for CML patients, and its implementation in clinical research and practice can provide important information to facilitate clinical decision-making. © 2013 Springer Science+Business Media Dordrecht.
Authors & Co-Authors
Efficace, Fabio
Italy, Rome
Data Center and Health Outcomes Research Unit
Baccarani, Michele
Italy, Bologna
Irccs Azienda Ospedaliero-universitaria Di Bologna
Breccia, Massimo
Italy, Rome
Sapienza Università Di Roma
Saussele, Susanne
Germany, Heidelberg
Universität Heidelberg
Abel, Gregory
United States, Boston
Dana-farber Cancer Institute
Caocci, G.
Italy, Cagliari
Università Degli Studi Di Cagliari
Guilhot, François
France, Poitiers
Centre Hospitalier Universitaire de Poitiers
Cocks, Kim
United Kingdom, York
University of York
Naeem, Adel
Iraq, Baghdad
Baghdad Teaching Hospital
Sprangers, Mirjam A.G.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Oerlemans, Simone
Netherlands, Eindhoven
Integraal Kankercentrum Zuid
Chie, Wei-Chu
Taiwan, Taipei
National Taiwan University
Castagnetti, Fausto
Italy, Bologna
Irccs Azienda Ospedaliero-universitaria Di Bologna
Bombaci, Felice
Italy, Torino
Gruppo Ail Pazienti Lmc
Sharf, Giora
Israel, Tel Aviv-yafo
Cml Advocates Network
Cardoni, Annarita
Italy, Rome
Data Center and Health Outcomes Research Unit
Noens, Lucien A.
Belgium, Ghent
Universitair Ziekenhuis Gent
Pallua, Stephan
Austria, Innsbruck
Medizinische Universitat Innsbruck
Salvucci, Marzia
Italy, Ravenna
Hematology and Bmt Unit
Nicolatou-Galitis, Ourania
Greece, Athens
National and Kapodistrian University of Athens
Rosti, Gianantonio
Italy, Bologna
Irccs Azienda Ospedaliero-universitaria Di Bologna
Mandelli, Franco
Italy, Rome
Data Center and Health Outcomes Research Unit
Statistics
Citations: 70
Authors: 22
Affiliations: 18
Identifiers
Doi:
10.1007/s11136-013-0523-5
ISSN:
09629343
Research Areas
Cancer
Disability
Health System And Policy
Study Design
Cross Sectional Study
Study Approach
Quantitative