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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Screening of some Tanzanian medicinal plants for their trypanocidal and cytotoxic activities
Phytotherapy Research, Volume 24, No. 6, Year 2010
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Description
The objective of the present study was to evaluate in vitro antitrypanosomal and cytotoxic activities of crude extracts of 20 traditionally used medicinal plants of Tanzania. A total of 40 extracts (dichloromethane and methanol) were screened for antiproliferative activity of bloodstream form of T. b. brucei and human leukaemia HL-60 cell. Inhibition of cell proliferation was assessed using resazurin as vital stain. Of the 40 extracts tested, the dichloromethane extract from bark of Warburgia salutaris (Canellaceae) exhibited the most potent antitrypanosomal activity with an IC50 value of 10.68 μg/ml. A dichloromethane extract from Lannea stuhlmannii (Anacardiaceae) was found to be the most cytotoxic extract against HL-60 (IC50 = 27.15 μg/ml). Out of the 20 plants tested, 5 plants exhibited trypanocidal activity with IC50 values below 20 μg/ml. These 5 plants: Entandrophragma bussei (Meliaceae), Securidaca longepedunculata (Polygalaceae), Warburgia salutaris (Canellaceae), Zanha africana (Sapindaceae) and Zanthoxylum chalybeum (Rutaceae) could therefore serve as sources of lead compounds for treatment of trypanosomiasis. Copyright © 2009 John Wiley & Sons, Ltd.
Authors & Co-Authors
Nibret, Endalkachew
Germany, Heidelberg
Universität Heidelberg
Ashour, Mohamed Lotfy
Germany, Heidelberg
Universität Heidelberg
Rubanza, Chrispinus D.K.
Tanzania, Morogoro
Tanzania Forestry Research Institute
Wink, Michael
Germany, Heidelberg
Universität Heidelberg
Statistics
Citations: 62
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1002/ptr.3066
ISSN:
0951418X
e-ISSN:
10991573
Study Locations
Tanzania