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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
G2019S LRRK2 mutation in French and North African families with Parkinson's disease
Annals of Neurology, Volume 58, No. 5, Year 2005
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Description
Mutations in LRRK2 were recently identified in autosomal dominant Parkinson's disease (PD), including the G2019S mutation. To evaluate its frequency, we analyzed 198 probands with autosomal dominant PD, mostly from France and North Africa. Surprisingly, the frequency in North African families (7/17, 41%) was greater than those from Europe (5/174, 2.9%). The clinical features in 21 patients, including 1 with a homozygous mutation, were those of typical PD, with lower Mini-Mental State Examination scores. There were also 15 unaffected mutation carriers, aged 32 to 74 years. LRRK2 mutations appear to be a common cause of autosomal dominant PD, particularly in North Africa. © 2005 American Neurological Association.
Authors & Co-Authors
Lesage, Suzanne
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Ibáñez, Pablo
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Lohmann, Ebba
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Pollak, Pierre R.
France, Grenoble
Centre Hospitalier Universitaire de Grenoble
Tison, François X.
France, Pessac
Hopital Haut-lévêque C.h.u de Bordeaux
Tazir, Mériem
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Leutenegger, Anne Louise
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Guimarães, João
Portugal, Lisbon
Centro Hospitalar de Lisboa Ocidental Hospital de Egas Moniz
Bonnet, Anne Marie
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Agid, Yves A.
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Dürr, Alexandra
France, Paris
Hôpital Universitaire Pitié Salpêtrière
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Brice, Alexis
France, Paris
Hôpital Universitaire Pitié Salpêtrière
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Statistics
Citations: 193
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1002/ana.20636
ISSN:
03645134
Research Areas
Cancer
Study Locations
Multi-countries