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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of acyclovir on HIV-1 set point among herpes simplex virus type 2 seropositive persons during early HIV-1 infection
Journal of Infectious Diseases, Volume 202, No. 5, Year 2010
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Description
We evaluated whether acyclovir suppression during human immunodeficiency virus type 1 (HIV-1) acquisition reduces HIV-1 set point, increases CD4 cell counts, and selects reverse- transcriptase mutations among 76 HIV-1 seroconverters identified in a placebo-controlled trial of twice-daily acyclovir (400 mg) for the prevention of HIV acquisition in herpes simplex virus type 2 (HSV-2)-seropositive persons(HIV Prevention Trials Network study 039). We found no significant difference in plasma HIV-1 RNA levels (Pp.30) or CD4 cell counts (Pp.85) between the acyclovir and placebo recipients. V75I and other mutations in HIV-1 reverse transcriptase reported from in vitro acyclovir studies were not observed. In conclusion, acyclovir suppression during HIV-1 seroconversion and the subsequent 6 months does not affect HIV-1 set point. © 2010 by the Infectious Diseases Society of America.
Authors & Co-Authors
Nina Kim, Hyang Nina
United States, Seattle
Harborview Medical Center
Wang, Jing
United States, Seattle
Fred Hutchinson Cancer Research Center
Hughes, James P.
United States, Seattle
Fred Hutchinson Cancer Research Center
Coombs, Robert W.
Unknown Affiliation
Sánchez, Jorge L.
United States
Asociacion Civil Impacta Salud y Educacion Impacta
Reid, Stewart E.
United States, Birmingham
The University of Alabama at Birmingham
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
Delany-Moretlwe, Sinead
South Africa, Johannesburg
University of the Witwatersrand
Cowan, Frances Mary
United Kingdom, London
University College London
Fuchs, Jonathan D.
United States, San Francisco
San Francisco Department of Public Health
Eshleman, Susan H.
United States, Baltimore
Johns Hopkins School of Medicine
Khaki, Leila
United States, Seattle
Fred Hutchinson Cancer Research Center
McMahon, Moira A.
United States, Baltimore
Johns Hopkins School of Medicine
Siliciano, Robert F.
United States, Baltimore
Johns Hopkins School of Medicine
Wald, Anna
United States, Seattle
Fred Hutchinson Cancer Research Center
Celum, Connie L.
United States, Seattle
University of Washington
Statistics
Citations: 15
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1086/655662
ISSN:
00221899
Research Areas
Infectious Diseases