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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth
Cancer Research, Volume 73, No. 12, Year 2013
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Description
Activation of the transcription factor PPARγ by the n-3 fatty acid docosahexaenoic acid (DHA) is implicated in controlling proinflammatory cytokine secretion, but the intracellular signaling pathways engaged by PPARγ are incompletely characterized. Here, we identify the adapter-encoding gene SOCS3 as a critical transcriptional target of PPARγ. SOCS3 promoter binding and gene transactivation by PPARγ was associated with a repression in differentiation of proinflammatory T-helper (TH)17 cells. Accordingly, TH17 cells induced in vitro displayed increased SOCS3 expression and diminished capacity to produce interleukin (IL)-17 following activation of PPARγ by DHA. Furthermore, naïve CD4 T cells derived from mice fed a DHA-enriched diet displayed less capability to differentiate into TH17 cells. In two different mouse models of cancer, DHA prevented tumor outgrowth and angiogenesis in an IL-17-dependent manner. Altogether, our results uncover a novel molecular pathway by which PPARγ-induced SOCS3 expression prevents IL-17-mediated cancer growth. ©2013 AACR.
Authors & Co-Authors
Berger, Hélène
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Végran, Frédérique
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Chikh, Madijd
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Gilardi, Federica
Switzerland, Lausanne
Université de Lausanne Unil
Ladoire, Sylvain
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Bugaut, Hél̀ene
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Mignot, Grégoire
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Chalmin, Fanny
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Bruchard, Mélanie
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Dérangère, Valentin
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Chevriaux, Angélique
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Rébé, Cédric
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Ryffel, Bernhard
France, Orleans
University and Cnrs
South Africa, Cape Town
University of Cape Town
Pot, Caroline
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Switzerland, Geneva
Université de Genève
Hichami, Aziz
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Desvergne, Béatrice
Switzerland, Lausanne
Université de Lausanne Unil
Ghiringhelli, François
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Apétoh, Lionel
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Statistics
Citations: 53
Authors: 18
Affiliations: 8
Identifiers
Doi:
10.1158/0008-5472.CAN-12-4018
ISSN:
00085472
e-ISSN:
15387445
Research Areas
Cancer
Genetics And Genomics