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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Presence and characterization of insulin-like growth factor 1 receptors in human benign breast disease
European Journal of Cancer and Clinical Oncology, Volume 24, No. 9, Year 1988
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Description
Insulin-like growth factor 1 binding sites were characterized in human benign breast disease. We demonstrated the presence of one high affinity binding site. Chemical cross-linking of [125I]IGF1 to benign breast disease membranes in reducing condition and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) revealed one band with an apparent Mr of 130,000. The specificity of the binding was studied: IGF 2 was a good competitor whereas insulin competed for binding with a potency lower than 1 100 that of IGF1. This IGF1 binding corresponded to the previously described type 1 IGF receptor (IGF1-R). IGF1-R was assayed in 35 cases of benign breast disease and two samples of normal breast tissue. Forty-three per cent of the lesions were IGF1-R positive. The mean geometric level of specific binding was 1.98% in the whole population, it was significantly lower in adenofibromas (1.55%) than in epithelial hyperplasia (2.5%); it was 2% in dystrophic disease. IGF1-R was undetectable in normal tissue. Considering our previous results showing that almost all the breast cancers contained IGF1-R, these data suggest that the increase in IGF1-R could be a marker of malignant tumor development. © 1988.
Authors & Co-Authors
Peyrat, Jean Philippe
France, Lille
Centre Oscar Lambret
Bonneterre, Jacques M.
France, Lille
Centre Oscar Lambret
Louchez, Marie Michèle
France, Lille
Centre Oscar Lambret
Amrani, S.
France, Lille
Centre Oscar Lambret
Statistics
Citations: 32
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/0277-5379(88)90332-X
ISSN:
02775379
Research Areas
Cancer
Study Design
Cross Sectional Study