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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma
Journal of Immunology, Volume 176, No. 3, Year 2006
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Description
Human airway smooth muscle cells (HASMC) secrete fractalkine (FKN), a chemokine the concentration of which is increased in asthmatic patients. HASMC also induce mast cell chemotaxis, as a component of asthma inflammation. We therefore evaluated the role of smooth muscle-derived FKN in mast cell migration. We assessed the capacity of recombinant FKN to induce human mast cell chemotaxis. This effect implicates a calcium-independent pathway involving actin reorganization and protein kinase C-δ. We found that HASMC constitutively produce FKN, the synthesis of which is reinforced upon proinflammatory stimulation. Under basal experimental conditions, FKN production by HASMC is not sufficient to induce mast cell chemotaxis. However, pretreatment of mast cells with the neuropeptide vasoactive intestinal peptide (VIP) increases FKN potency to attract mast cells. Since we observed, in asthmatic patients, an increase in both FKN and VIP expression by airway smooth muscle and a positive correlation between VIP staining and mast cell infiltration of the smooth muscle layer, we conclude that HASMC-derived FKN may contribute to mast cell recruitment in asthma. Copyright © 2006 by The American Association of Immunologists, Inc.
Authors & Co-Authors
El-Shazly, Amr E.
France, Bordeaux
Université de Bordeaux
Egypt, 6th October
Misr University for Science and Technology
Berger, Patrick
France, Bordeaux
Université de Bordeaux
Girodet, Pierre Olivier
France, Bordeaux
Université de Bordeaux
Ousova, Olga
France, Bordeaux
Université de Bordeaux
Fayon, Michaël John
France, Bordeaux
Université de Bordeaux
Vernejoux, Jean Marc
France, Pessac
Hopital Haut-lévêque C.h.u de Bordeaux
Marthan, Roger
France, Bordeaux
Université de Bordeaux
Tunon-De-Lara, J. Manuel
France, Bordeaux
Université de Bordeaux
France, Pessac
Hopital Haut-lévêque C.h.u de Bordeaux
Statistics
Citations: 169
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.4049/jimmunol.176.3.1860
ISSN:
00221767