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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers
Journal of the National Cancer Institute, Volume 104, No. 2, Year 2012
Notification
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Description
Background The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case-control studies conducted in regions with differing Background risks of esophageal cancer. Methods We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case-control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression with adjustment for smoking, alcohol consumption, and other potential confounders. Pooled odds ratios and 95% confidence intervals were calculated using either a linear mixed-effects approach or a joint fixed-effects approach. All statistical tests were two-sided. ResultsWe found statistically significant associations between esophageal squamous cell carcinoma and antibodies to E6 for HPV16 (OR = 1.89, 95% CI = 1.09 to 3.29, P =. 023) and HPV6 (OR = 2.53, 95% CI = 1.51 to 4.25, P <. 001) but not for other tested HPV types. There were no statistically significant associations between esophageal squamous cell carcinoma and antibodies to E7 for any of the tested HPV types. Simultaneous seropositivity for HPV16 E6 and E7 was rare (four case subjects, two control subjects; OR = 5.57, 95% CI = 0.90 to 34.35; P =. 064). We also found statistically significant associations between esophageal squamous cell carcinoma and capsid antibodies for the high-risk mucosal type HPV33 L1 (OR = 1.30, 95% CI = 1.00 to 1.69; P =. 047) and the low-risk mucosal types HPV6 (OR = 1.22, 95% CI = 1.05 to 1.42; P =. 010) and HPV11 (OR = 1.30, 95% CI = 1.09 to 1.56, P =. 0036). Conclusions We found limited serological evidence of an association between esophageal squamous cell carcinoma and HPV in the populations studied. Although HPV does not appear to be an important risk factor for esophageal squamous cell carcinoma, we cannot exclude the possibility that certain HPV types may be involved in a small subset of cancers. © 2012 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3260131/bin/supp_104_2_147__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3260131/bin/supp_djr499_DJR499_jnci-JNCI-11-0571-s01.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3260131/bin/supp_djr499_DJR499_jnci-JNCI-11-0571-s02.pdf
Authors & Co-Authors
Sitas, F.
Australia, Woolloomooloo
Cancer Council Nsw
Egger, Sam J.
Australia, Woolloomooloo
Cancer Council Nsw
Urban, Margaret I.
South Africa, Johannesburg
University of the Witwatersrand
United States, New York
Icahn School of Medicine at Mount Sinai
Taylor, Philip R.
United States, Rockville
National Cancer Institute Nci
South Africa, Johannesburg
National Health Laboratory Service
Abnet, Christian C.
United States, Rockville
National Cancer Institute Nci
South Africa, Johannesburg
National Health Laboratory Service
Boffetta, Paolo A.
France, Dardilly
International Prevention Research Institute
O'Connell, Dianne L.
Australia, Woolloomooloo
Cancer Council Nsw
Whiteman, David C.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Brennan, Paul J.
France, Lyon
Centre International de Recherche Sur le Cancer
Malekzadeh, Reza
Iran, Tehran
Digestive Diseases Research Center
Pawlita, Michael
Germany, Heidelberg
German Cancer Research Center
Dawsey, Sanford M.
United States, Rockville
National Cancer Institute Nci
South Africa, Johannesburg
National Health Laboratory Service
Waterboer, Tim
Germany, Heidelberg
German Cancer Research Center
Webb, Penelope M.
Unknown Affiliation
Green, Adele C.
Unknown Affiliation
Hayward, Nicholas K.
Unknown Affiliation
Zaridze, D.
Unknown Affiliation
Holcatova, Ivana
Unknown Affiliation
Mates, Dana
Unknown Affiliation
Szeszenia-Dabrowska, Neonila
Unknown Affiliation
Ferro, Gilles
Unknown Affiliation
Janout, Vladimír
Unknown Affiliation
Curado, Maria Paula
Unknown Affiliation
Menezes, Ana Maria Baptista
Unknown Affiliation
Koifman, Sérgio
Unknown Affiliation
Islami, Farhad
Unknown Affiliation
Nasrollahzadeh, Dariush
Unknown Affiliation
Hu, Nan
Unknown Affiliation
Goldstein, Alisa M.
Unknown Affiliation
Gao, Ying
Unknown Affiliation
Ding, Ti
Unknown Affiliation
Kamangar, Farin
Unknown Affiliation
Statistics
Citations: 81
Authors: 32
Affiliations: 10
Identifiers
Doi:
10.1093/jnci/djr499
ISSN:
00278874
e-ISSN:
14602105
Research Areas
Cancer
Substance Abuse
Study Design
Case-Control Study