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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L
Journal of Ethnopharmacology, Volume 129, No. 1, Year 2010
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Description
Aim of the study: The dichloromethane extract prepared from aerial parts of Ageratum conyzoides L. (Asteraceae), a plant commonly used in folk medicine for a number of illnesses including sleeping sickness, was recently found to exhibit a prominent activity (IC50=0.78μg/mL) against bloodstream forms of Trypanosoma brucei rhodesiense, the etiologic agent of East African Human Trypanosomiasis (East African Sleeping Sickness). This extract also exhibited noticeable activities against Leishmania donovani (Kala-Azar, IC50=3.4μg/mL) as well as Plasmodium falciparum (Malaria tropica, IC50=8.0μg/mL). In the current study, we sought for potentially active constituents of Ageratum conyzoides. Materials and methods: Extracts prepared with solvents of different polarity were tested for activity against the above mentioned parasites as well as against Trypanosoma cruzi (Chagas' disease) and for cytotoxicity using established protocols. The dicholoromethane extract showed the highest level of activity and was chosen for phytochemical studies aimed at the isolation of potential active constituents. Results and conclusion: Five highly methoxylated flavonoids along with the chromene derivative encecalol methyl ether were isolated. All isolated compounds were previously reported from Ageratum conyzoides. While the chromene turned out to be inactive against the tested parasites, the flavonoids showed activity against the protozoan pathogens, some in the lower micromolar range. However, none of these isolated compounds was as active as the crude extract. This is the first report on antiprotozoal activity of this plant species and some of its constituents. The chemical principle accounting for the high activity of the crude extract, however, remains to be identified. © 2010 Elsevier Ireland Ltd.
Authors & Co-Authors
Nour, Amal M.M.
Germany, Munster
University of Münster
Khalid, Sami Ahmed
Sudan, Khartoum
Ministry of Science and Technology
Kaiser, Marcel
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Brun, Reto
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Abdalla, Wai'l E.
Sudan, Khartoum
Medicinal and Aromatic Plants Research Institute
Schmidt, Thomas Jürgen
Germany, Munster
University of Münster
Statistics
Citations: 98
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.jep.2010.02.015
ISSN:
03788741
Research Areas
Health System And Policy
Infectious Diseases