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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup B
Journal of Infectious Diseases, Volume 198, No. 5, Year 2008
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Description
Background. Nasopharyngeal carriage of meningococcus or related species leads to protective immunity in adolescence or early adulthood. This natural immunity is associated with mucosal and systemic T cell memory. Whether parenteral Neisseria meningitidis serogroup B (MenB) vaccination influences natural mucosal immunity is unknown. Objectives. To determine whether parenteral MenB vaccination affects mucosal immunity in young adults and whether this immunity differs from that induced in the blood. Methods. Otherwise healthy volunteers were immunized with MenB outer membrane vesicle vaccine before and after routine tonsillectomy. Mucosal and systemic immunity were assessed in 9 vaccinees and 12 unvaccinated control subjects by measuring mononuclear cell proliferation, cytokine production, Th1/Th2 surface marker expression, and antibody to MenB antigens. Results. Parenteral vaccination induced a marked increase in systemic T cell immunity against MenB and a Th1 bias. In contrast, although mucosal T cell proliferation in response to MenB neither increased nor decreased following vaccination, mononuclear cell interferon γ, interleukin (IL)-5, and IL-10 production increased, and the Th1/Th2 profile lost its Th1 bias. Conclusions. Parenteral MenB vaccination selectively reprograms preexisting naturally acquired mucosal immunity. As new-generation protein-based MenB vaccine candidates undergo evaluation, the impact of these vaccines on mucosal immunity in both adults and children will need to be addressed. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Davenport, Victoria
United Kingdom, Bristol
University of Bristol
United Kingdom, Bristol
University of the West of England
Groves, Eleanor
United Kingdom, Bristol
University of Bristol
United Kingdom, London
Imperial College London
Horton, Rachel E.
United Kingdom, Bristol
University of Bristol
Canada, Winnipeg
Max Rady College of Medicine, University of Manitoba
Hobbs, Christopher G.L.
United Kingdom, Bristol
Bristol Veterinary School
United Kingdom, Birmingham
Heartlands Hospital
Guthrie, Terry
United Kingdom, Bristol
University of Bristol
United Kingdom, Cleveland
Avecia Vaccines
Findlow, Jamie
United Kingdom, Manchester
Manchester Royal Infirmary
Borrow, Ray
United Kingdom, Manchester
Manchester Royal Infirmary
Næss, Lisbeth Meyer
Norway, Oslo
Folkehelseinstituttet
Oster, Philipp
Italy, Siena
Novartis Vaccines and Diagnostic S.r.l.
Heyderman, Robert Simon
United Kingdom, Bristol
University of Bristol
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Williams, Neil A.
United Kingdom, Bristol
University of Bristol
Statistics
Citations: 36
Authors: 11
Affiliations: 11
Identifiers
Doi:
10.1086/590669
ISSN:
00221899
Research Areas
Maternal And Child Health