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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Uterus transplantation in a non-human primate: Long-term follow-up after autologous transplantation
Human Reproduction, Volume 27, No. 6, Year 2012
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Description
Background: Uterus transplantation (UTx) may provide the first available treatment for women affected by uterine infertility. The present study aimed to further develop a surgical technique for autologous UTx in a non-human primate species and to assess long-term function. Methods Female baboons (n 16) underwent autologous transplantation of the uterus with the Fallopian tubes and ovaries, performed with a previously published surgical technique (n 6, Group 1) or using a modified technique (n 10; Group 2). The uterine arteries were dissected to the proximal end of the anterior branch (Group 1) or the entire (Group 2) internal iliac artery, and the ovarian veins were dissected to the crossing over the ureter (Group 1) or further cranially to include greater lengths and patches of the cava/renal vein (Group 2). Back-table preparation created common venous and arterial ends with arterial anastomosis either end-to-side to the left external iliac artery (Group 1) or end-to-end to the left internal iliac artery (Group 2). Results Overall short-time survival of the animals was 88 (66 in Group 1 and 100 in Group 2). Of all the operated animals, 75 (66 in Group 1 and 80 in Group 2) resumed ovarian cyclicity. Regular menstruation after UTx was demonstrated only in Group 2 (60). Menstruating animals (n 6) were each exposed to timed mating for <5 menstrual cycles, but pregnancy did not occur. Adhesions and tubal blockage were seen in post-mortem analysis. Conclusions The modified UTx model of Group 2 is a safe procedure and shows resumed long-term uterine function in a majority of the animals, although pregnancy could not be demonstrated. © 2012 The Author.
Authors & Co-Authors
Johannesson, L.
Sweden, Gothenburg
Göteborgs Universitet
Enskog, A.
Sweden, Gothenburg
Sahlgrenska Akademin
Dahm-Kähler, Pernilla
Sweden, Gothenburg
Göteborgs Universitet
Hanafy, A.
Australia, Brisbane
Griffith University
Chai, Daniel C.
Kenya, Nairobi
National Museums of Kenya
Mwenda, Jason Mathiu
Kenya, Nairobi
National Museums of Kenya
Díaz-García, César
Sweden, Gothenburg
Göteborgs Universitet
Sweden, Gothenburg
Sahlgrenska Akademin
Olausson, M.
Spain, Valencia
Hospital Universitari I Politècnic la fe
Brännström, Mats
Sweden, Gothenburg
Göteborgs Universitet
Statistics
Citations: 71
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1093/humrep/des093
ISSN:
02681161
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female