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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Induction of neutralizing antibodies and cytotoxic T lymphocytes in Balb/c mice immunized with virus-like particles presenting a gp120 molecule from a HIV-1 isolate of clade A
Antiviral Research, Volume 54, No. 3, Year 2002
Notification
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Description
We have recently developed a candidate HIV-1 vaccine based on virus-like particles (VLPs) expressing a gp120 from an Ugandan HIV-1 isolate of the clade A (HIV-VLPAs). In vivo immunogenicity experiments were performed in Balb/c mice, with an immunization schedule based on a multiple-dose regimen of HIV-VLPAs without adjuvants, showing a significant induction of both humoral and cellular immunity. The Env-specific cellular response was investigated in vitro, scoring for both the proliferative response of T helper cells and the cytolytic activity of cytotoxic T lymphocytes (CTLs). Furthermore, immune sera showed >50% neutralization activity against both the autologous field isolate and the heterologous T cell adapted B-clade HIV-1IIIB viral strain. This is one of the first examples of HIV-1 vaccines based on antigens derived from the A clade, which represents >25% of all isolates identified world wide. In particular, the A clade is predominant in sub-Saharan countries, where 70% of the global HIV-1 infections occur, and where vaccination is the only rational strategy for an affordable prevention against HIV-1 infection. © 2002 Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Buonaguro, Luigi
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Racioppi, L.
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Tornesello, Maria Lina
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Arra, Claudio
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Visciano, Maria Luisa
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Biryahwaho, Benon
Uganda, Entebbe
Uganda Virus Research Institute
Sempala, Sylvester D.K.
Uganda, Entebbe
Uganda Virus Research Institute
Giraldo, Gaetano
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Buonaguro, Franco Maria
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Statistics
Citations: 77
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/S0166-3542(02)00004-9
ISSN:
01663542
Research Areas
Infectious Diseases
Maternal And Child Health