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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Specific protein assays in protein-calorie malnutrition
Clinica Chimica Acta, Volume 62, No. 1, Year 1975
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Description
Assessment of serum protein concentrations in protein-calorie malnutrition was carried out by two specific immunochemical methods, the Single Radial Immunodiffusion technique and the Automated Immunonephelometric procedure. The correlation coefficient (r) between the two methods was above 0.85 for all the serum proteins assayed. The automated nephelometric assay procedure has the advantages that it is rapid and that a large number of samples can be readily processed. The system in its present form could not be readily used to quantitate proteins such as prealbumin whose serum concentration was less than 50 mg/100 ml. The single radial immunodiffusion technique gave more consistent results for IgA estimation than the automated technique. With the exception of C4 and the immunoglobulins, all the serum proteins assayed were lower in children with protein-calorie malnutrition than in control children. During refeeding in children with protein-calorie malnutrition the first serum protein to show a significant rise was C3. This was followed by transferrin, then prealbumin and lastly albumin. C4 did not show any significant change. In experimental protein-calorie malnutrition in rats, the first serum protein to show a significant reduction was C3. This was followed by transferrin and then albumin. On the rats these serum proteins returned to normal values in the same order. © 1975.
Authors & Co-Authors
Olusi, S. O.
United Kingdom, Manchester
The University of Manchester
Nigeria, Ibadan
U.c.h.
McFarlane, Hylton
United Kingdom, Manchester
The University of Manchester
Osunkoya, B. O.
Nigeria, Ibadan
U.c.h.
Adesina, H.
United Kingdom, Manchester
The University of Manchester
Nigeria, Ibadan
U.c.h.
Statistics
Citations: 4
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/0009-8981(75)90286-7
ISSN:
00098981
Research Areas
Food Security
Maternal And Child Health