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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A 84-month follow up of adherence to HAART in a cohort of adult Senegalese patients
Tropical Medicine and International Health, Volume 12, No. 10, Year 2007
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Description
Objectives: To assess long-term adherence of the first HIV-1 patients receiving highly active antiretroviral therapy (HAART) in Senegal, and to identify the main determinants of adherence. Methods: The first 180 patients enrolled in the Senegalese HAART initiative between August 1998 and April 2001 followed up for at least 30 days were eligible. Adherence was assessed monthly at each drug dispensation between November 1999 and November 2006 by a pharmacist using a pill count completed by a questionnaire. Adherence was expressed as the proportion of tablets taken to prescribed tablets. An adherence of 95% was considered to be good. A random-intercept logit model was fitted to identify the main determinants of adherence. Results: Adherence data were available for 158 of 167 eligible patients. Twenty-nine patients died during the study period and 10 were lost to follow-up. Median treatment duration was 78 months, accruing to 6657 person-months of observation. Overall, mean adherence reached 91% [median: 100%, interquartile range (IQR) 96-100%] and adherence exceeded 95% in 78% [95% CI 77-79%] of observations. After 4 years of treatment mean adherence stabilized around 90% and adherence ≥95% stabilized around 70%. Treatment duration and protease inhibitor (PI)-based regimen (indinavir) had a negative effect on adherence, but adherence tended to improve with time for patients receiving a PI. Patient-level variance was highly significant and accounted for a third of total variance. Conclusions: This work demonstrates that good long-term adherence can be achieved in the sub-Saharan context given close monitoring and adherence support measures, confirms the worse adherence for indinavir and underlines the importance of patient heterogeneity. © 2007 Blackwell Publishing Ltd.
Authors & Co-Authors
Étard, Jean François
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
France, Montpellier
Université de Montpellier
Laniéce, Isabelle
Senegal, Dakar
Service de Coopération et D'action Culturelle, Dakar
Fall, Mame Basty Koita
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Cilote, Vannina
Senegal, Dakar
Service de Coopération et D'action Culturelle, Dakar
Blazejewski, Laure
France, Lyon
Chu de Lyon
France, Villeurbanne
Université Claude Bernard Lyon 1
Diop, Karim
Senegal, Dakar
Ministère de la Santé
Desclaux, Alice
France, Marseille
Aix Marseille Université
France, Aix-en-provence
Institut de Formation en Ecologie Humaine et Anthropologie
Écochard, René
France, Lyon
Chu de Lyon
France, Villeurbanne
Université Claude Bernard Lyon 1
Ndoye, Ibrahima
Senegal, Dakar
Conseil National de Lutte Contre le Sida
Delaporte, Éric
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
France, Montpellier
Université de Montpellier
Delaporte, Éric
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
France, Montpellier
Université de Montpellier
Laurent, Christian
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
France, Montpellier
Université de Montpellier
Taverne, Bernard
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
France, Montpellier
Université de Montpellier
Basty Fall, M.
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Dieng, Allé Baba
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Diouf, Assane M.
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Massidi, Christian
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Sarr, Anna
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Sow, Khoudia
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Zié, L.
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Ndiaye, Ibrahima Pierre
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Ndour, Cheikh Tidiane
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Sow, Papa Salif
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Ngom-Guèye, Ndèye Fatou
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Bâ-Fall, K. M.
Senegal, Dakar
Hôpital de Dakar
Guèye, Pape Mandoumbé
Senegal, Dakar
Hôpital de Dakar
Diaw, Papa Alassane
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Diop-Ndiaye, Halimatou
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Mboup, Souleymane
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Touré-Kane, Ndèye Coumba
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Ndiaye, Bara
Senegal
Centre Hospitalier National Universitaire de Fann
Statistics
Citations: 54
Authors: 31
Affiliations: 12
Identifiers
Doi:
10.1111/j.1365-3156.2007.01910.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Locations
Senegal