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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Allogeneic matched-sibling hematopoietic cell transplantation for AML: Comparable outcomes between Eastern Mediterranean (EMBMT) and European (EBMT) centers
Bone Marrow Transplantation, Volume 48, No. 8, Year 2013
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Description
Allogeneic hematopoietic cell transplantation (HCT) activity significantly increased in the Eastern Mediterranean area over the past decade. However, comparative outcomes with longer established centers, especially European Blood and Marrow Transplantation (EBMT) centers, have not been reported. We compared outcomes of matched-sibling allogeneic HCT between East Mediterranean Blood and Marrow Transplantation (EMBMT) and EBMT centers for adult patients with AML in first CR using myeloablative conditioning. We matched 431 patients from EMBMT with 431 patients from EBMT centers according to patient, disease and transplant characteristics. EMBMT recipients and donors were more likely to be CMV seropositive. There were no significant differences in the incidence of acute or chronic GVHD, or the 3-year cumulative incidence of non-relapse mortality (NRM) and relapse incidence (RI) between the two groups (NRM: EMBMT=16% vs EBMT=11), (RI: EMBMT=13% vs EBMT=19%). Notably, the 3-year leukemia-free survival (LFS) and OS were similar between the groups (LFS: EMBMT=70±2% vs EBMT=69±3%), (OS: EMBMT=74±2% vs EBMT=73±2%). Despite differences in socioeconomics, health resources and transplant experience, matched-sibling allogeneic HCT outcomes in emerging centers in the EMBMT region appear similar to EBMT centers. © 2013 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Bazarbachi, Ali Abdul Hamid
Lebanon, Beirut
American University of Beirut Medical Center
Labopin, Myriam
France, Paris
Hôpital Saint-antoine
Ghavamzadeh, Ardashir R.
Iran, Tehran
Hematology, Oncology and Stem Cell Transplantation Research Center
Giebel, Sebastian
Poland, Gliwice
Maria Sklodowska-curie National Research Institute of Oncology Gliwice Branch
Al-Zahrani, Hazzaa Abdulla
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Ladeb, Saloua
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Leone, Giuseppe
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Abdel-Rahman, Fawzi Latif
Jordan, Amman
King Hussein Cancer Center
Liso, Vincenzo
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Hamidieh, Amir Ali
Iran, Tehran
Hematology, Oncology and Stem Cell Transplantation Research Center
Rasheed, Walid
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Ibrahim, Ahmad O.
Lebanon, Beirut
Makassed General Hospital
Alabdulaaly, Abdulaziz
Saudi Arabia, Riyadh
Riyadh Military Hospital
Kyrcz-Krzemien, Slawomira
Poland, Katowice
Slaski Uniwersytet Medyczny w Katowicach
Arnold, Renate
Germany, Berlin
Charité – Universitätsmedizin Berlin
Kharfan-Dabaja, M.
Lebanon, Beirut
American University of Beirut Medical Center
Alimoghadam, Kamran
Iran, Tehran
Hematology, Oncology and Stem Cell Transplantation Research Center
Aljurf, Mahmoud Deeb
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Mohty, Mohamad
France, Nantes
Nantes Université
Statistics
Citations: 19
Authors: 19
Affiliations: 14
Identifiers
Doi:
10.1038/bmt.2013.1
ISSN:
02683369
e-ISSN:
14765365
Research Areas
Health System And Policy
Study Design
Cohort Study