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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol
Journal of the American College of Cardiology, Volume 78, No. 5, Year 2021
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Description
Background: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels. Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was <70 mg/dL (median 69.4 mg/dL; interquartile range: 64.3-74.0 mg/dL); in 14,573 patients (77.0%), both determinations were ≥70 mg/dL (median 94.0 mg/dL; interquartile range: 83.2-111.0 mg/dL). Results: In the lower LDL-C subgroup, MACE rates were 4.2 and 3.1 per 100 patient-years among placebo-treated patients with baseline lipoprotein(a) greater than or less than or equal to the median (13.7 mg/dL). Corresponding adjusted treatment hazard ratios were 0.68 (95% confidence interval [CI]: 0.52-0.90) and 1.11 (95% CI: 0.83-1.49), with treatment-lipoprotein(a) interaction on MACE (Pinteraction = 0.017). In the higher LDL-C subgroup, MACE rates were 4.7 and 3.8 per 100 patient-years among placebo-treated patients with lipoprotein(a) >13.7 mg/dL or ≤13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43. Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402) © 2021 The Authors
Authors & Co-Authors
Schwartz, Gregory G.
United States, Aurora
University of Colorado School of Medicine
Szarek, Michael J.
United States, Albany
State University of new York System
United States, Aurora
University of Colorado School of Medicine
Bittner, Vera A.
United States, Birmingham
The University of Alabama at Birmingham
Díaz, Rafaël J.
Argentina, Rosario
Etudios Cardiologica Latin America, Rosario
Goodman, Shaun G.
Canada, Edmonton
University of Alberta
Canada, Toronto
University of Toronto
Jukema, Johan Wouter
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Utrecht
Netherlands Heart Institute
Landmesser, Ulf E.
Germany, Berlin
Charité – Universitätsmedizin Berlin
López-Jaramillo, P.
Colombia, Bucaramanga
Universidad de Santander
Manvelian, Garen Z.
United States, Tarrytown
Regeneron Pharmaceuticals, Inc.
Pordy, Robert
United States, Tarrytown
Regeneron Pharmaceuticals, Inc.
Sinnaeve, Peter R.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
White, Harvey D.
New Zealand, Auckland
Auckland City Hospital
Steg, Philippe Gabriel
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
United Kingdom, London
Imperial College London
Bhatt, Deepak L.
Unknown Affiliation
Harrington, Robert A.
Unknown Affiliation
Zeiher, Andreas Michael
Unknown Affiliation
Tricoci, Pierluigi
Unknown Affiliation
Roe, Matthew T.
Unknown Affiliation
Mahaffey, Kenneth W.
Unknown Affiliation
Edelberg, Jay M.
Unknown Affiliation
Hanotin, Corinne
Unknown Affiliation
Lecorps, Guillaume
Unknown Affiliation
Moryusef, Angèle
Unknown Affiliation
Sasiela, William J.
Unknown Affiliation
Tamby, Jean François
Unknown Affiliation
Aylward, Philip E.
Unknown Affiliation
Drexel, Heinz
Unknown Affiliation
Dilić, Mirza
Unknown Affiliation
Lópes, Renato Deláscio
Unknown Affiliation
Gotcheva, Nina N.
Unknown Affiliation
Prieto, Juan Carlos D.
Unknown Affiliation
Yong, Huo
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Pečin, Ivan
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Reiner, Željko
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Ošťǎdal, Petr
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Poulsen, Steen Hvitfeldt
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Viigimaa, Margus
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Nieminen, Markku Sakari
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Danchin, Nicolas
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Chumburidze, Vakhtang
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Marx, Nikolaus
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Liberopoulos, Evangelos N.
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Tse, Hung Fat
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Kiss, Róbert Gábor
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Xavier, Denis
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Zahger, Doron
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Valgimigli, Marco
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Kimura, Takeshi
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Kim, Hyosoo
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Kim, Sanghyun
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Erglis, Andrejs
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LauceviÄius, Aleksandras
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Kedev, Saško A.
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Yusoff, Khalid
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Ramos López, Gabriel Arturo
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Alings, Marco A.
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Halvorsen, Sigrun
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Correa Flores, Roger Martin
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Sy, Rody G.
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Budaj, Andrzej J.
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Morais, João Carlos Araujo
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Dorobanţu, Maria I.
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Ristić, Arsen D.
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Chua, Terrance S.J.
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Murín, Ján
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Fras, Zlatko
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Dalby, Anthony John
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Tuñón, José
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de Silva, Hithanadura Asita
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Hagström, Emil G.
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Müller, Christian E.
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Chiang, Chernen
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Sritara, Piyamitr
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Güneri, Sema
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Ray, Kausik Kumar
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Moriarty, Patrick Maurice
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Vogel, Robert A.
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Chaitman, Bernard R.
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Kelsey, Sheryl F.
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Olsson, Anders G.
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Rouleau, Jean Lucien
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Simoons, Maarten L.
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Alexander, Karen P.
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Meloni, Chiara
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Rosenson, Robert Sidney
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Sijbrands, Eric J.G.
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Alexander, John Hunter P.
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Bagai, Akshay
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Van-Diepen, Sean F.P.
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Schiavi, Lilia Beatriz
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Garrido, Marcelo A.
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Bordonava, Anselmo Paulino
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Duronto, Ernesto A.
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Novaretto, Leonardo P.
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Hominal, Miguel Angel
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Montaña, Oscar R.
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Caccavo, Alberto
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Gomez Vilamajó, Oscar Alberto
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Lorenzatti, Alberto J.
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Cartasegna, Luis Rodolfo
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MacKinnon, Ignacio J.
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Bono, Julio Oscar Emilio
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Hrabar, Adrián D.
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Ahuad-Guerrero, Rodolfo Andres
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Zaidman, Cesar Javier
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Dran, Ricardo Dario
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Vico, Marisa Liliana
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Bustamante-Labarta, Miguel H.
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Nani, Sebastián
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Luciardi, Héctor Lucas
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Waisman, Gabriel Darío
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Garcia-Duran, Ruben Omar
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Cestari, Horacio G.
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Lúquez, Hugo A.
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Zapata, Gerardo O.
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Costamagna, Osvaldo J.A.
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Shaw, James A.M.
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Horowitz, John D.
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Colquhoun, David M.
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Lehman, Sam J.
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Terzic´, Ibrahim
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Fazlibegović, Emir
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Muslibegovic, Adis
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Reis, Gilmar
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Nicolau, José Carlos
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Maia, Lília Nigro
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Rossi, Paulo R.F.
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Yuan, Zuyi
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Ge, Junbo
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Molina, Dora Ines
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Leclercq, Florence L.
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Delarche, Nicolas
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Boccara, Franck
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Paganelli, Franck F.
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Clerc, Jérôme
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Hemetsberger, Rayyan
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Stellbrink, Christoph
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Werner, Christian M.
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Nuding, Sebastian
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Winkelmann, Bernhard Rudolf
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Karakas, Mahir
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Münzel, Tomas F.
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Manolis, Athanasios John
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Athyros, Vasilios Gabriel
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Vardas, Panos E.
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Lekakis, John P.
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Merkely, Béla D.Signla
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Ungi, Imre
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Sandhu, Manjinder Singh
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Premchand, Rajendra Kumar
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Kerkar, Prafulla Gopinath
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Groenemeijer, Björn E.
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Coman, Ioan Mircea
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Dimulescu, Doina Ruxandra
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Statistics
Citations: 54
Authors: 314
Affiliations: 16
Identifiers
Doi:
10.1016/j.jacc.2021.04.102
ISSN:
07351097
Research Areas
Environmental
Health System And Policy
Noncommunicable Diseases
Study Design
Randomised Control Trial