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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
EMBO Journal, Volume 27, No. 1, Year 2008
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Description
TASK1 (KCNK3) and TASK3 (KCNK9) are two-pore domain potassium channels highly expressed in adrenal glands. TASK1/TASK3 heterodimers are believed to contribute to the background conductance whose inhibition by angiotensin II stimulates aldosterone secretion. We used task1-/- mice to analyze the role of this channel in adrenal gland function. Task1-/- exhibited severe hyperaldosteronism independent of salt intake, hypokalemia, and arterial 'low-renin' hypertension. The hyperaldosteronism was fully remediable by glucocorticoids. The aldosterone phenotype was caused by an adrenocortical zonation defect. Aldosterone synthase was absent in the outer cortex normally corresponding to the zona glomerulosa, but abundant in the reticulo-fasciculata zone. The impaired mineralocorticoid homeostasis and zonation were independent of the sex in young mice, but were restricted to females in adults. Patch-clamp experiments on adrenal cells suggest that task3 and other K+ channels compensate for the task1 absence. Adrenal zonation appears as a dynamic process that even can take place in adulthood. The striking changes in the adrenocortical architecture in task1-/- mice are the first demonstration of the causative role of a potassium channel in development/differentiation. ©2008 European Molecular Biology Organization.
Authors & Co-Authors
Heitzmann, Dirk
Germany, Regensburg
Universität Regensburg
Bandulik, Sascha
Germany, Regensburg
Universität Regensburg
Sterner, Christina
Germany, Regensburg
Universität Regensburg
Schweda, Frank
Germany, Regensburg
Universität Regensburg
El Wakil, Abeer
France, Paris
Cnrs Centre National de la Recherche Scientifique
Lalli, Enzo
France, Paris
Cnrs Centre National de la Recherche Scientifique
Guy, Nicolas
France, Paris
Cnrs Centre National de la Recherche Scientifique
Reichold, Markus
Germany, Regensburg
Universität Regensburg
Bendahhou, Saïd
France, Paris
Cnrs Centre National de la Recherche Scientifique
Gómez-Sánchez, Celso Enrique
United States
Va Medical Center
Weber, Achim
Switzerland, Zurich
Universitatsspital Zurich
Lesage, Florian
France, Paris
Cnrs Centre National de la Recherche Scientifique
Warth, R.
Germany, Regensburg
Universität Regensburg
Barhanin, Jacques
France, Paris
Cnrs Centre National de la Recherche Scientifique
Statistics
Citations: 164
Authors: 14
Affiliations: 7
Identifiers
Doi:
10.1038/sj.emboj.7601934
ISSN:
14602075
Research Areas
Noncommunicable Diseases
Participants Gender
Female