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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Proinflammatory responses and higher IL-10 production by T cells correlate with protection against malaria during pregnancy and delivery outcomes
Journal of Immunology, Volume 194, No. 7, Year 2015
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Description
Pregnancy triggers immunological changes aimed to tolerate the fetus. However, it has not been properly addressed whether similar changes occur in tropical areas with high infection pressure and whether these changes render women more susceptible to infectious diseases. We compared the frequencies of T cell subsets, including regulatory T cells, in pregnant and nonpregnant women from Papua New Guinea, a high malaria transmission area, and from Spain, a malaria-free country. We also assessed the relationship among these cellular subsets, malaria infection, and delivery outcomes. CD4+FOXP3+CD127low T cells (Tregs) were decreased in pregnant women in both countries but were not associated with malaria infection or poor delivery outcomes. An expansion of IFN-γ- producing cells and intracytoplasmic IFN-γ levels was found in pregnant compared with nonpregnant women only in Papua New Guinea. Increased CD4+IL-10+IFN-γ+ frequencies and Treg-IFN-γ production were found in women with current Plasmodium falciparum infection. Higher CD4+IL-10-IFN-γ+ T cells frequencies and production of proinflammatory cytokines (including TNF and IL-2) at recruitment (first antenatal visit) had a protective association with birth weight and future (delivery) P. falciparum infection, respectively. Higher intracellular IL-10 levels in T cells had a protective association with future P. falciparum infection and hemoglobin levels at delivery. The protective associations were found also with nonmalaria-specific T cell responses. Treg frequencies positively correlated with plasma eotaxin concentrations, but this subset did not express eotaxin receptor CCR3. Thus, an activated immune system during pregnancy might contribute to protection against malaria during pregnancy and poor delivery outcomes. Copyright © 2015 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Requena, Pilar
Spain, Barcelona
Instituto de Salud Global de Barcelona
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Barrios, Diana
Spain, Barcelona
Instituto de Salud Global de Barcelona
Robinson, Leanne J.
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Umbers, Alexandra J.
Australia, Melbourne
University of Melbourne
Wangnapi, Regina Alice
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Ome-Kaius, Maria
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Rosanas-Urgell, Anna
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Mayor, A. G.
Spain, Barcelona
Instituto de Salud Global de Barcelona
López, Marta J.
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
de Làzzari, Elisa
Spain, Barcelona
Instituto de Salud Global de Barcelona
Arev́alo-Herrera, Myriam
Colombia, Cali
Caucaseco Scientific Research Center
Fernandez-Becerra, C.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Del Portillo, Hernando A.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Chitnis, Chetan E.
India, New Delhi
International Centre for Genetic Engineering and Biotechnology, new Delhi
Siba, Peter Max
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Rogerson, Stephen J.
Australia, Melbourne
University of Melbourne
Mueller, Ivo
Spain, Barcelona
Instituto de Salud Global de Barcelona
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Bardají, Azucena
Spain, Barcelona
Instituto de Salud Global de Barcelona
Menéndez, Clara
Spain, Barcelona
Instituto de Salud Global de Barcelona
Dobaño, Carlota
Spain, Barcelona
Instituto de Salud Global de Barcelona
Statistics
Citations: 17
Authors: 20
Affiliations: 10
Identifiers
Doi:
10.4049/jimmunol.1401038
ISSN:
00221767
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Locations
Guinea
Participants Gender
Female