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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Preferential in-utero transmission of HIV-1 subtype C as compared to HIV-1 subtype A or D
AIDS, Volume 18, No. 12, Year 2004
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Description
Objective: To determine whether different HIV-1 genotypes present in a single cohort, in Dar es Salaam, Tanzania, showed differences in timing for transmission from mothers to their infants. Methods: We determined the maternal viral load, transmission time, and the HIV-1 envelope (env) subtype of 253 HIV-1-infected infants enrolled in a randomized double-blind placebo-controlled trial to examine the efficacy of vitamins in decreasing mother-to-child transmission in Tanzania. Classification of HIV-1 positivity in utero was based on PCR results at birth. Infants were classified as intrapartum infected if they scored negative for the sample collected at birth and positive for the sample collected at 6 weeks of age. Results: We found significant differences in the distribution of transmission time according to subtype. A higher proportion of HIV-1 with subtype C env (C-env) was transmitted in utero than HIV-1 with subtype A env (A-env), subtype D env (D-env), or both combined. Conclusions: The identification of patterns of mother-to-child transmission times among HIV-1 genotypes may be useful in the selection of drug regimens for chemoprophylaxis. Based on our results, the efficacy of regimens administered only at labor may not protect as large a fraction of infants born in geographical regions with subtype C-env epidemics as compared to epidemics in regions where subtypes A-env and D-env predominate in the population. © 2004 Lippincott Williams & Wilkins.
Authors & Co-Authors
Renjifo, Boris R.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Gilbert, Peter B.
United States, Seattle
Fred Hutchinson Cancer Research Center
Chaplin, Beth R.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Msamanga, Gernard I.
Tanzania, Dar es Salaam
Muhimbili Medical Centre
Mwakagile, Davis S.M.
Tanzania, Dar es Salaam
Muhimbili Medical Centre
Fawzi, Wafaie W.
United States, Boston
Harvard T.h. Chan School of Public Health
Essex, Max E.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Statistics
Citations: 153
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1097/01.aids.0000131392.68597.34
Research Areas
Disability
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Tanzania