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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synergy of ferrous ion on 5-aminolevulinic acid-mediated growth inhibition of Plasmodium falciparum
Journal of Biochemistry, Volume 154, No. 6, Year 2013
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Description
Haem biosynthesis appeared to be a target of malaria therapy because 5-aminolevulinic acid (ALA), a haem biosynthesis starting material, with light exposure or a high amount of ALA alone reduced Plasmodium falciparum growth to undetectable level. However, the administration of a high dose of ALA is unrealistic for clinical therapy. We found that Fe2+ enhanced P. falciparum-killing potency of ALA and significantly inhibited the parasite growth. The intermediates of haem biosynthesis localized to the parasite organelles, and coproporphyrin III was the most accumulated intermediate. These novel findings may lead to development of a new anti-malarial drug using ALA and Fe2+. © The Authors 2013. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.
Authors & Co-Authors
Komatsuya, Keisuke
Japan, Tokyo
Graduate School of Medicine
Hata, Masayuki
Japan, Tokyo
Graduate School of Medicine
Balogun, Emmanuel Oluwadare
Japan, Tokyo
Graduate School of Medicine
Japan, Kyoto
Kyoto Institute of Technology
Nigeria, Zaria
Ahmadu Bello University
Hikosaka, Kenji
Japan, Tokyo
Graduate School of Medicine
Suzuki, Shigeo
Japan, Tokyo
Graduate School of Medicine
Japan, Tokyo
Sbi Pharmaceuticals Co., Ltd.
Takahashi, Kiwamu
Japan, Tokyo
Sbi Pharmaceuticals Co., Ltd.
Tanaka, Tohru
Japan, Tokyo
Sbi Pharmaceuticals Co., Ltd.
Nakajima, Motowo
Japan, Tokyo
Sbi Pharmaceuticals Co., Ltd.
Ogura, Shun Ichiro
Japan, Tokyo
Tokyo Institute of Technology
Sato, Shigeharu
United Kingdom, London
Mrc National Institute for Medical Research
Kita, Kiyoshi
Japan, Tokyo
Graduate School of Medicine
Statistics
Citations: 13
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1093/jb/mvt096
ISSN:
0021924X
e-ISSN:
17562651
Research Areas
Infectious Diseases