Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression
Scientific Reports, Volume 11, No. 1, Article 7772, Year 2021
Notification
URL copied to clipboard!
Description
The inhibitory effects of programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) modulates T-cell depletion. T-cell depletion is one of the key mechanisms of hepatitis B virus (HBV) persistence, in particular liver disease progression and the development of hepatocellular carcinoma (HCC). This case–control study aimed to understand the significance of PD-1 polymorphisms (PD-1.5 and PD-1.9) association with HBV infection risk and HBV-induced liver disease progression. Genotyping of PD-1.5 and PD-1.9 variants was performed by direct Sanger sequencing in 682 HBV-infected patients including chronic hepatitis (CHB, n = 193), liver cirrhosis (LC, n = 183), hepatocellular carcinoma (HCC, n = 306) and 283 healthy controls (HC). To analyze the association of PD-1 variants with liver disease progression, a binary logistic regression, adjusted for age and gender, was performed using different genetic models. The PD-1.9 T allele and PD-1.9 TT genotype are significantly associated with increased risk of LC, HCC, and LC + HCC. The frequencies of PD-1.5 TT genotype and PD-1.5 T allele are significantly higher in HCC compared to LC patients. The haplotype CT (PD-1.5 C and PD-1.9 T) was significantly associated with increased risk of LC, HCC, and LC + HCC. In addition, the TC (PD-1.5 T and PD-1.9 C) haplotype was associated with the risk of HCC compared to non-HCC. The PD-1.5 CC, PD-1.9 TT, genotype, and the CC (PD-1.5 C and PD-1.9) haplotype are associated with unfavorable laboratory parameters in chronic hepatitis B patients. PD-1.5 and PD1.9 are useful prognostic predictors for HBV infection risk and liver disease progression. © 2021, The Author(s).
Authors & Co-Authors
Hoan, Nghiem Xuan
Viet Nam, Hanoi
108 Institute of Clinical Medical and Pharmaceutical Sciences
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research Vg-care
Germany, Tubingen
Eberhard Karls Universität Tübingen
Binh, Mai Thanh
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research Vg-care
Viet Nam, Hanoi
108 Institute of Clinical Medical and Pharmaceutical Sciences
Trung, Ngo Tat
Viet Nam, Hanoi
108 Institute of Clinical Medical and Pharmaceutical Sciences
Giang, Dao Phuong
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research Vg-care
Pallerla, Srinivas Reddy
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kremsner, Peter G.
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research Vg-care
Germany, Tubingen
Eberhard Karls Universität Tübingen
Velavan, Thirumalaisamy P.
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research Vg-care
Germany, Tubingen
Eberhard Karls Universität Tübingen
Bang, Maihong
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research Vg-care
Viet Nam, Hanoi
108 Institute of Clinical Medical and Pharmaceutical Sciences
Song, Lehuu
Viet Nam, Hanoi
108 Institute of Clinical Medical and Pharmaceutical Sciences
Viet Nam, Hanoi
Vietnamese-german Center for Medical Research Vg-care
Statistics
Citations: 4
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1038/s41598-021-87537-9
ISSN:
20452322
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases