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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Male antenatal attendance and HIV testing are associated with decreased infant HIV infection and increased HIV-free survival
Journal of Acquired Immune Deficiency Syndromes, Volume 56, No. 1, Year 2011
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Description
Objective: To investigate the relationship between male involvement in prevention of mother-to-child HIV transmission services and infant HIV acquisition and mortality, a prospective cohort study was undertaken between 1999 and 2005 in Nairobi, Kenya. Methods: HIV-infected pregnant women were enrolled and followed with their infants for 1 year with infant HIV DNA testing at birth, 1, 3, 6, 9, and 12 months postpartum. Women were encouraged to invite male partners for prevention counseling and HIV testing. Results: Among 456 female participants, 140 partners (31%) attended the antenatal clinic. Eighty-two (19%) of 441 infants tested were HIV infected by 1 year of age. Adjusting for maternal viral load, vertical transmission risk was lower among women with partner attendance compared with those without [adjusted hazard ratio (aHR) = 0.56, 95% confidence interval (CI): 0.33 to 0.98; P = 0.042] and among women reporting versus not reporting previous partner HIV testing (aHR = 0.52, 95% CI: 0.32 to 0.84; P = 0.008). The combined risk of HIV acquisition or infant mortality was lower with male attendance (aHR = 0.55; 95% CI: 0.35 to 0.88; P = 0.012) and report of prior male HIV testing (aHR = 0.58; 95% CI: 0.34 to 0.88; P = 0.01) when adjusting for maternal viral load and breastfeeding. Conclusions: Including men in antenatal prevention of mother-to-child HIV transmission services with HIV testing may improve infant health outcomes. © 2010 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Aluisio, Adam R.
United States, Stony Brook
Stony Brook University Hospital
Richardson, Barbra Ann
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Bosire, Rose Kerubo
Kenya, Nairobi
Kenya Medical Research Institute
John-Stewart, Grace C.
United States, Seattle
University of Washington
Mbori-Ngacha, Dorothy A.
Kenya, Nairobi
University of Nairobi
Farquhar, Carey
United States, Seattle
University of Washington
Statistics
Citations: 267
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1097/QAI.0b013e3181fdb4c4
ISSN:
15254135
Research Areas
Environmental
Genetics And Genomics
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Kenya
Participants Gender
Male
Female