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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Toxicity of rhizonin A, isolated from Rhizopus microsporus, in laboratory animals
Food and Chemical Toxicology, Volume 22, No. 4, Year 1984
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Description
Maize culture material of 25 isolates of the genera Rhizopus and Mucor caused deaths in day-old unsexed Pekin ducklings when fed as a 50% (w/w) mixture with duckling feed. Nine of these isolates were tested for toxicity in young inbred male BD IX rats, which were fed a mixture of 50% (w/w) culture material and rat feed. Only one isolate of Rhizopus microsporus was clearly toxic, causing 100% mortality in rats within 10 days. Growth in rats was reduced by adding culture material of this isolate to the feed in concentrations of 2.5, 5, 10 or 20% (w/w). The same isolate of R. microsporus was used to produce the mycotoxin rhizonin A. Pure rhizonin A was dissolved in dimethylsulphoxide and given to young male partially inbred albino rats by gavage in single doses of 70, 96, 131 or 180 mg/kg. The lowest dose exceeded the LD100. Evaluated by light microscopy, lesions in livers and kidneys were similar in rats fed culture material and in those intubated with rhizonin A. Hepatocytes showed changes ranging from degeneration to necrosis, the liver-tissue architecture was changed by disassociation of liver cell cords and there was periportal bile-duct proliferation. Renal tubular epithelium showed changes ranging from degeneration to necrosis. © 1984.
Authors & Co-Authors
Wilson, Terrance M.
United States, University Park
Pennsylvania State University
Rabie, Christiaan J.
South Africa, Tygerberg
National Research Institute for Nutritional Diseases Tygerberg
Fincham, John E.
South Africa, Tygerberg
National Research Institute for Nutritional Diseases Tygerberg
Steyn, Pieter S.
South Africa, Pretoria
National Chemical Research Laboratory
Schipper, Maria A.A.
Netherlands, Utrecht
Westerdijk Fungal Biodiversity Institute - Knaw
Statistics
Citations: 46
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/0278-6915(84)90006-1
ISSN:
02786915
Research Areas
Environmental
Participants Gender
Male