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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers
Mucosal Immunology, Volume 5, No. 3, Year 2012
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Description
The predominance of HIV-1 sexual transmission requires a greater understanding of the interaction between HIV-1 and the mucosal immune system. The study of HIV-1-exposed seronegative (HESN) individuals serves as a model to identify the correlates of protection and to aid in microbicide development. A total of 22 cytokines/chemokines were analyzed at the systemic and mucosal compartments in 57 HESN, 51 HIV-1-negative, and 67 HIV-1-infected commercial sex workers from Nairobi, Kenya. HESN individuals had significantly lower expression of monokine induced by interferon-γ (MIG), interferon-γ- induced protein 10 (IP-10), and interleukin-1α (IL-1α) in their genital mucosa compared with controls. HESN cytokine expression also distinctly correlates with mucosal antiproteases, suggesting that HESN individuals have a unique pattern of mucosal chemokine/cytokine expression, which may result in reduced trafficking at the mucosa. These data support the immune quiescence model of protection, whereby lower T-cell activation/recruitment at the mucosal compartment reduces HIV-1 target cell numbers and is an important component of natural protection from HIV-1. © 2012 Society for Mucosal Immunology.
Authors & Co-Authors
Lajoie, Julie
Canada, Winnipeg
University of Manitoba
Juno, Jennifer A.
Canada, Winnipeg
University of Manitoba
Burgener, Adam D.
Canada, Winnipeg
University of Manitoba
Rahman, S.
Canada, Winnipeg
University of Manitoba
Birse, Kenzie D.M.
Canada, Winnipeg
University of Manitoba
Wachihi, Charles
Kenya, Nairobi
Kenyan Aids Control Program
Mwanjewe, J.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
Kenyan Aids Control Program
Plummer, Francis Allan
Canada, Winnipeg
University of Manitoba
Canada, Ottawa
Public Health Agency of Canada
Kimani, Joshua
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
Kenyan Aids Control Program
Ball, Terry Blake
Canada, Winnipeg
University of Manitoba
Canada, Ottawa
Public Health Agency of Canada
Kenya, Nairobi
University of Nairobi
Fowke, Keith Raymond
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Statistics
Citations: 137
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1038/mi.2012.7
ISSN:
19330219
e-ISSN:
19353456
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Locations
Kenya