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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antiretroviral therapy initiated during acute HIV infection fails to prevent persistent T-cell activation
Journal of Acquired Immune Deficiency Syndromes, Volume 62, No. 5, Year 2013
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Description
Initiation of antiretroviral therapy during acute HIV-1 infection may prevent persistent immune activation. We analyzed longitudinal CD38+HLA-DR+ CD8+ T-cell percentages in 31 acutely infected individuals who started early (median 43 days since infection) and successful antiretroviral therapy, and maintained viral suppression through 96 weeks. Pretherapy a median of 72.6% CD8+ T cells were CD38+HLA-DR+, and although this decreased to 15.6% by 96 weeks, it remained substantially higher than seronegative controls (median 8.9%, P = 0.008). Shorter time to suppression predicted lower activation at 96 weeks. These results support the hypothesis that very early events in HIV-1 pathogenesis may result in prolonged immune dysfunction. Copyright © 2012 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Vinikoor, Michael J.
United States, Atlanta
National Center for Infectious Diseases
Gay, Cynthia L.
United States, Atlanta
National Center for Infectious Diseases
Ferrari, Guido
United States, Durham
Duke University
Lennox, Jeffrey L.
United States, Atlanta
Emory University
Hicks, Charles B.
United States, Durham
Duke University
Eron, Joseph J.
United States, Atlanta
National Center for Infectious Diseases
Statistics
Citations: 46
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1097/QAI.0b013e318285cd33
ISSN:
10779450
Research Areas
Infectious Diseases
Study Design
Cohort Study