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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Role of N-acetylglucosamine within core lipopolysaccharide of several species of Gram-negative bacteria in targeting the DC-SIGN (CD209)
Journal of Immunology, Volume 177, No. 6, Year 2006
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Description
Our recent studies have shown that the dendritic cell-specific ICAM nonintegrin CD209 (DC-SIGN) specifically binds to the core LPS of Escherichia coli K12 (E. coli), promoting bacterial adherence and phagocytosis. In this current study, we attempted to map the sites within the core LPS that are directly involved in LPS-DC-SIGN interaction. We took advantage of four sets of well-defined core LPS mutants, which are derived from E. coli, Salmonella enterica serovar Typhimurium, Neisseria gonorrhoeae, and Haemophilus ducreyi and determined interaction of each of these four sets with DC-SIGN. Our results demonstrated that N-acetylglucosamine (GlcNAc) sugar residues within tine core LPS in these bacteria play an essential role in targeting the DC-SIGN receptor. Our results also imply that DC-SIGN is an innate immune receptor and the interaction of bacterial core LPS and DC-SIGN may represent a primeval interaction between Gram-negative bacteria and host phagocytic cells. Copyright © 2006 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Zhang, Pei
United States, Chicago
University of Illinois at Chicago
Azadi, Parastoo
United States, Athens
University of Georgia
Zhang, Shusheng
United States, Chicago
University of Illinois at Chicago
Bulgheresi, Silvia
Austria, Vienna
Universität Wien
Sanderson, Kenneth E.
Unknown Affiliation
He, Jianglin Jingyuan
United States, Indianapolis
Indiana University School of Medicine
Klena, John David
New Zealand, Christchurch
University of Canterbury
Chen, Tie
United States, Chicago
University of Illinois at Chicago
Statistics
Citations: 75
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.4049/jimmunol.177.6.4002
ISSN:
00221767
Research Areas
Infectious Diseases