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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The effect of melatonin on eye lens of rats exposed to ultraviolet radiation
Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, Volume 129, No. 1, Year 2001
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Description
We investigated the influence of exogenously administered melatonin on adult rats eye lenses exposed to ultraviolet radiation (UV) A and B ranging from 356-254 nm irradiation at 8 μW/cm2. Rats exposed to this range of UV for 15 min for one week showed a significant (P < 0.05) reduction in antioxidant enzymes activities; superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and elevated (P < 0.001) lipid peroxidation served as an index of cellular damage by free radicals. UV-radiation significantly (P < 0.001) elevated calcium ions (Ca2+) and lactate dehydrogenase (LDH) activity in lenses. Depleting animals of their stores of important intracellular antioxidant and elevating lenticular Ca2+ by UV irradiation, may be the main cause of lens opacification. Melatonin injection with radiation significantly reduced (P < 0.05) lipid peroxidation, Ca2+ and (P < 0.001) for LDH. When melatonin was injected after radiation, SOD and GSH-Px enzyme activities increased significantly (P < 0.01), and lipid peroxidation, Ca2+ levels and LDH activities were reduced significantly. Melatonin injection after UV radiation was as effective as melatonin treatment concurrent with UV irradiation. We conclude that melatonin may protect the eye lens from the damaging effects of UV exposure, and its actions protect lens from oxidative stress, elevating Ca2+ levels, which are considered as an important causes of cataractogenesis. © 2001 Elsevier Science Inc.
Authors & Co-Authors
Anwar, Mamdouh M.
Egypt, Asyut
Faculty of Medicine
Moustafa, Mohsen A.
Egypt, Cairo
Al-azhar University
Statistics
Citations: 40
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/S1532-0456(01)00180-6
ISSN:
15320456
Research Areas
Cancer
Health System And Policy