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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Treatment results and prognostic factors of pediatric neuroblastoma: A retrospective study
International Archives of Medicine, Volume 3, No. 1, Article 37, Year 2010
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Description
Background: We conducted a retrospective analysis to investigate treatment results and prognostic factors of pediatric neuroblastoma patients. Methods. This retrospective study was carried out analyzing the medical records of patients with the pathological diagnosis of neuroblastoma seen at South Egypt Cancer Institute, Assiut University during the period from January 2001 and January 2010. After induction chemotherapy, response according to international neuoblastoma response criteria was assessed. Radiotherapy to patients with residual primary tumor was applied. Overall and event free survival (OAS and EFS) rates were estimated using Graphed prism program. The Log-rank test was used to examine differences in OAS and EFS rates. Cox-regression multivariate analysis was done to determine the independent prognostic factors affecting survival rates. Results. Fifty three cases were analyzed. The median follow-up duration was 32 months and ranged from 2 to 84 months. The 3-year OAS and EFS rates were 39.4% and 29.3% respectively. Poor prognostic factors included age 1 year of age, N-MYC amplification, and high risk group. The majority of patients (68%) presented in high risk group, where treatment outcome was poor, as only 21% of patients survived for 3 year. Conclusion. Multivariate analysis confirmed only the association between survival and risk group. However, in univariate analysis, local radiation therapy resulted in significant survival improvement. Therefore, radiotherapy should be given to patients with residual tumor evident after induction chemotherapy and surgery. Future attempts to improve OAS in high risk group patients with aggressive chemotherapy and bone marrow transplantation should be considered. © 2010 El-Sayed et al; licensee BioMed Central Ltd.
Authors & Co-Authors
El-Sayed, Mohamed Ibrahim
Egypt, Asyut
Assiut University
Ali, Amany Mohamed
Egypt, Asyut
Assiut University
Sayed, Heba Abdel Razik
Egypt, Asyut
Assiut University
Mosad, Eman
Egypt, Asyut
Faculty of Medicine
Statistics
Citations: 21
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1186/1755-7682-3-37
e-ISSN:
17557682
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study
Study Locations
Egypt