Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Isoniazid resistance without a loss of fitness in Mycobacterium tuberculosis
Nature Communications, Volume 3, Article 753, Year 2012
Notification
URL copied to clipboard!
Description
The emergence of multi- and extensively drug-resistant tuberculosis (MDR-TB and XDR-TB, respectively) has intensified the critical public health implications of this global disease. The fitness of Mycobacterium tuberculosis (M.tb.) strains exhibiting MDR and XDR phenotypes is of fundamental importance in predicting whether the MDR-/XDR-TB epidemic will be sustained across the human population. Here we describe a potential mechanism of M.tb. resistance to the TB drug isoniazid (INH) conferred by loss of a sigma factor, SigI. We demonstrate that the gain of INH resistance in the M.tb. ΔsigI mutant might not diminish the organism's fitness for causing disease. These findings have significant implications when considering the ability of drug-resistant M.tb. strains to initiate untreatable TB epidemics, as it is possible that loss or alteration of SigI function could have a role in the generation of MDR and XDR M.tb. strains of suitable fitness to spread in a community setting. © 2012 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Lee, Jong Hee
United States, Baltimore
Johns Hopkins University
Ammerman, Nicole C.
United States, Baltimore
Johns Hopkins University
Nolan, Scott
United States, Baltimore
Johns Hopkins University
Geiman, Deborah E.
United States, Baltimore
Johns Hopkins University
Lun, Shichun
United States, Baltimore
Johns Hopkins University
Guo, Haidan
United States, Baltimore
Johns Hopkins University
Bishai, William R.
United States, Baltimore
Johns Hopkins University
South Africa, Durban
Africa Health Research Institute
United States, Chevy Chase
Howard Hughes Medical Institute
Statistics
Citations: 39
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1038/ncomms1724
e-ISSN:
20411723
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study