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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Cryptosporidiosis in kuwaiti children: Association of clinical characteristics with cryptosporidium species and subtypes
Journal of Medical Microbiology, Volume 60, No. 5, Year 2011
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Description
To determine the association of clinical characteristics with Cryptosporidium types and subtypes, faecal specimens from 2548 children with diarrhoea were screened by microscopy for Cryptosporidium spp., and positive specimens were genotyped and subtyped by PCR-RFLP. A total of 87 of the 2548 children (3.4%) had cryptosporidial diarrhoea by microscopy and the majority (41.4%) of the infected children were in the 4-8-year-old age group. Molecular characterization of the 83 children studied further (4 had mixed infections and were not subtyped) showed that Cryptosporidium parvum was the most commonly identified species (73.5%) and consisted of three subtypes: IIa and IId were the most common (80.3%), followed by IIc. Twenty- two (26.5%) of the children had Cryptosporidium hominis and showed three subtypes: Id was the most common (54.5%), followed by Ia (36.4%) and Ie. Associated clinical manifestations varied between C. parvum and C. hominis. Diarrhoea associated with subtype Id, the most commonly identified C. hominis subtype, was more severe than that associated with other subtypes. In conclusion, this study confirmed a very different Cryptosporidium genotype and subtype distribution compared with other tropical countries among Kuwaiti children with diarrhoea, with a predominance of C. parvum IIa and IId. In addition, subtype Id of C. hominis was associated with more diverse and severe clinical manifestations in infected children, suggesting that parasite genetics may play an important role in the clinical manifestations of human cryptosporidiosis. © 2011 SGM.
Authors & Co-Authors
Iqbal, Jamshaid R.
Kuwait, Kuwait City
Kuwait University
Khalid, Nabila
Kuwait, Kuwait City
Kuwait University
Hira, Parsotam Ravjee
Kuwait, Kuwait City
Kuwait University
Statistics
Citations: 65
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1099/jmm.0.028001-0
ISSN:
00222615
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health