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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Child-Pugh-Turcott versus Meld score for predicting survival in a retrospective cohort of black African cirrhotic patients
World Journal of Gastroenterology, Volume 14, No. 2, Year 2008
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Description
Aim: To compare the performance of the Child-Pugh-Turcott (CPT) score to that of the model for end-stage liver disease (MELD) score in predicting survival of a retrospective cohort of 172 Black African patients with cirrhosis on a short and mid-term basis. Methods: Univariate and multivariate (Cox model) analyses were used to identify factors related to mortality. Relationship between the two scores was appreciated by calculating the correlation coefficient. The Kaplan Meier method and the log rank test were used to elaborate and compare survival respectively. The Areas Under the Curves were used to compare the performance between scores at 3, 6 and 12 mo. Results: The study population comprised 172 patients, of which 68.9% were male. The mean age of the patient was 47.5 ± 13 years. Hepatitis B virus infection was the cause of cirrhosis in 70% of the cases. The overall mortality was 31.4% over 11 years of follow up. Independent factors significantly associated with mortality were: CPT score (HR = 3.3, 95% CI [1.7-6.2]) (P < 0.001) (stage C vs stage A-B); Serum creatine (HR = 2.5, 95% CI [1.4-4.3]) (P = 0.001) (Serum creatine > 1.5 mg/dL versus serum creatine < 1.5 mg/dL); MELD score (HR = 2.9, 95% CI [1.63-5.21]) (P < 0.001) (MELD > 21 vs MELD < 21). The area under the curves (AUC) that predict survival was 0.72 and 0.75 at 3 mo (P = 0.68), 0.64 and 0.62 at 6 mo (P = 0.67), 0.69 and 0.64 at 12 mo (P = 0.38) respectively for the CPT score and the MELD score. Conclusion: The CPT score displays the same prognostic significance as does the MELD score in black African patients with cirrhosis. Moreover, its handling appears less cumbersome in clinical practice as compared to the latter. © 2008 WJG. All rights reserved.
Authors & Co-Authors
Attia, Alain Koffi
Cote D'ivoire, Abidjan
Yopougon Teaching Hospital
Cote D'ivoire, Abidjan
University Hospital of Yopougon
Ackoundou-N'guessan, Clément
Cote D'ivoire, Abidjan
Yopougon Teaching Hospital
N'dri-yoman, A. T.
Cote D'ivoire, Abidjan
Yopougon Teaching Hospital
Mahassadi, Alassan Kouamé
Cote D'ivoire, Abidjan
Yopougon Teaching Hospital
Messou, Eugéne
Cote D'ivoire, Abidjan
Research and Training on Hiv/aids Infection and Related Diseases
Bathaix, Y. F.
Cote D'ivoire, Abidjan
Yopougon Teaching Hospital
Kissi, Y. H.
Cote D'ivoire, Abidjan
Yopougon Teaching Hospital
Statistics
Citations: 49
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.3748/wjg.14.286
ISSN:
10079327
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male