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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Immunovirological analyses of chronically simian immunodeficiency virus SIVmnd-1- and SIVmnd-2-infected mandrills (mandrillus sphinx)
Journal of Virology, Volume 85, No. 24, Year 2011
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Description
Simian immunodeficiency virus (SIV) infection in African nonhuman primate (NHP) natural hosts is usually nonpathogenic, despite high levels of virus replication. We have previously shown that chronic SIV infection in sooty mangabeys (SMs) and African green monkeys (AGMs) is associated with low levels of immune activation and bystander T cell apoptosis. To compare these features with those observed in another natural host, the mandrill (MND), we conducted a cross-sectional survey of the 23 SIV-infected and 25 uninfected MNDs from the only semifree colony of mandrills available worldwide. Viral loads (VLs) were determined and phenotypic and functional analysis of peripheral blood- and lymph node-derived lymphocytes was performed. We found that mandrills chronically infected with SIVmnd-1 or SIVmnd-2 have similar levels of viral replication, and we observed a trend toward lower CD4 + T cell counts in chronically SIVmnd-2-infected MNDs than SIVmnd-1-infected MNDs. No correlation between CD4 + T cell counts and VLs in SIV-infected MNDs could be established. Of note, the levels of T cell activation, proliferation, and apoptosis were comparable between SIVmnd-1- and SIVmnd-2-infected MNDs and to those observed in uninfected animals, with the only exception being an increase in tumor necrosis factor alpha-producing CD8 + T cells in SIVmnd-2-infected MNDs. Overall, these findings recapitulate previous observations in SIV-infected SMs and AGMs and lend further evidence to the hypothesis that low levels of immune activation protect natural SIV hosts from disease progression. © 2011, American Society for Microbiology.
Authors & Co-Authors
Apétrei, C.
United States, Pittsburgh
University of Pittsburgh School of Medicine
Sumpter, Beth
United States, Atlanta
Emory University School of Medicine
United States, Atlanta
Emory University
Souquière, Sandrine
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Chahroudi, Ann
United States, Atlanta
Emory University
Makuwa, Maria
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Reed, Patricia E.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Ribeiro, Ruy M.
United States, Los Alamos
Los Alamos National Laboratory
Pandrea, Ivona Vasile
United States, Pittsburgh
University of Pittsburgh School of Medicine
Roques, Pierre A.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Gif-sur-yvette
Institut Des Maladies Emergentes et Des Thérapies Innovantes
Silvestri, Guido Do
United States, Atlanta
Emory University School of Medicine
United States, Atlanta
Emory University
Statistics
Citations: 24
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1128/JVI.05693-11
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Cancer
Study Design
Cross Sectional Study
Study Approach
Quantitative