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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The role of compartment penetration in PI-Monotherapy: The Atazanavir-Ritonavir Monomaintenance (ATARITMO) Trial
AIDS, Volume 21, No. 10, Year 2007
Notification
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Description
OBJECTIVES: To limit exposure to anti-HIV drugs and minimize risk of long-term side effects, studies have looked at the possibility of simplified maintenance strategies. Ritonavir-boosted protease-inhibitor (PI)-monotherapies are an attractive alternative, but limited compartmental penetration of PI remains a concern. DESIGN: Non-comparative 24-week pilot study. METHOD: Ritonavir-boosted atazanavir (ATV/r) monotherapy administered to fully suppressed patients (>3 month HIV RNA < 50 copies/ml). Plasma was obtained every 4 weeks and cerebrospinal fluid (CSF) and semen at W24. RESULTS: Two patients (7%) failed ATV/r monotherapy. One patient was subsequently identified as a protocol violator since he had a previous history of treatment failure under indinavir. The second patient deliberately decided to stop treatment after W20. Excluding failing patients, individual measurements of HIV RNA in patients having occasional viral 'blips' was found in five patients. At W24, 3/20 patients had elevated viral loads in CSF (HIV RNA > 100 copies/ml), and 2/15 in semen, despite viral suppression in plasma (< 50 copies/ml). Samples with elevated HIV RNA (> 500 copies/ml) in CSF were all wild type. The mean ATV drug concentration ratio (CSF/blood, n = 22) was 0.9%. Indicators of altered immune activation (CD8CD38 C-reactive protein) remained unchanged. CONCLUSION: This study supports previous results indicating the potential use of PI-based mono-maintenance therapies. However, our results in CSF cautions against the uncontrolled use of PI-based monotherapies. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Vernazza, Pietro Luigi
Switzerland, St Gallen
Kantonsspital St.gallen
Décosterd, Laurent Arthur
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Klimkait, Thomas
Switzerland, Basel
Universitat Basel
Hoffmann, Matthias
Switzerland, St Gallen
Kantonsspital St.gallen
Hirschel, B. J.
Switzerland, Geneva
University Hospital
Battegay, Manuel
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Bernasconi, Enos
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Böni, Jürg
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Bucher, Heiner C.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Bürgisser, Ph
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Cattacin, Sandro
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Cavassini, Matthias L.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Dubs, Rolf W.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Egger, Matthias
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Elzi, Luigia
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Erb, Peter
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Fischer, Marek
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Flepp, Markus J.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Fontana, Adriano
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Francioli, Patrick B.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Furrer, Hansjakob
Unknown Affiliation
Gorgievski, Meri
Unknown Affiliation
Günthard, Hüldrych Fritz
Unknown Affiliation
Hirsch, Hans H.
Unknown Affiliation
Hirschel, B.
Unknown Affiliation
Hösli, Irene Mathilde
Unknown Affiliation
Kahlert, Christian R.
Unknown Affiliation
Kaiser, Laurent K.
Unknown Affiliation
Karrer, Urs
Unknown Affiliation
Kind, Christian H.
Unknown Affiliation
Ledergerber, Bruno
Unknown Affiliation
Martinetti, Gladys
Unknown Affiliation
Martinez, Begogna
Unknown Affiliation
Müller, Nicolas J.
Unknown Affiliation
Nadal, David
Unknown Affiliation
Opravil, Milos
Unknown Affiliation
Paccaud, Fred Michel
Unknown Affiliation
Pantaleo, Giuseppe P.
Unknown Affiliation
Rickenbach, Martin
Unknown Affiliation
Rudin, Christoph
Unknown Affiliation
Schmid, Patrick
Unknown Affiliation
Schültze, Detlev
Unknown Affiliation
Schüpbach, Jörg Rg
Unknown Affiliation
Speck, Roberto F.
Unknown Affiliation
Taffé, Patrick
Unknown Affiliation
Tarr, Philip E.
Unknown Affiliation
Telenti, Amalio
Unknown Affiliation
Trkola, Alexandra
Unknown Affiliation
Weber, Rainer
Unknown Affiliation
Yerly, Sabine T.B.D.
Unknown Affiliation
Statistics
Citations: 107
Authors: 50
Affiliations: 4
Identifiers
Doi:
10.1097/QAD.0b013e32814e6b1c
ISSN:
02699370
Research Areas
Health System And Policy
Infectious Diseases