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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro
Journal of Antimicrobial Chemotherapy, Volume 60, No. 5, Year 2007
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Description
Objectives: To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline on pneumolysin production by a macrolide-susceptible strain and two macrolide-resistant strains [erm(B) or mef(A)] of Streptococcus pneumoniae. Methods: Pneumolysin was assayed using a functional procedure based on the influx of Ca2+ into human neutrophils. Results: Only the macrolides/macrolide-like agents caused significant attenuation of the production of pneumolysin, which was evident with all three strains of the pneumococcus. Conclusions: Macrolides, at sub-MICs, but not other classes of antibiotic, subvert the production of pneumolysin, even in the presence of (and irrespective of the mechanism of) macrolide resistance in S. pneumoniae. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
Authors & Co-Authors
Anderson, Ronald
South Africa, Pretoria
Faculty of Health Sciences
Steel, Helen C.
South Africa, Pretoria
Faculty of Health Sciences
Cockeran, Riana
South Africa, Pretoria
Faculty of Health Sciences
von Gottberg, Anne M.
South Africa, Tygerberg
South African Medical Research Council
de Gouveia, Linda D.
South Africa, Tygerberg
South African Medical Research Council
Klugman, K. P.
South Africa, Tygerberg
South African Medical Research Council
United States, Atlanta
Emory University
Mitchell, Timothy J.
United Kingdom, Glasgow
University of Glasgow
Feldman, Charles
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 60
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1093/jac/dkm338
ISSN:
03057453
e-ISSN:
14602091
Research Areas
Cancer