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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Functional properties of the HIV-1 subtype C envelope glycoprotein associated with mother-to-child transmission
Virology, Volume 400, No. 2, Year 2010
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Description
Understanding the properties of viruses capable of establishing infection during perinatal transmission of HIV-1 is critical for designing effective means of limiting transmission. We previously demonstrated that the newly transmitted viruses (in infant) were more fit in growth, as imparted by their envelope glycoproteins, than those in their corresponding mothers. Here, we further characterized the viral envelope glycoproteins from six mother-infant transmission pairs and determined whether any specific envelope functions correlate with HIV-1 subtype C perinatal transmission. We found that most newly transmitted viruses were less susceptible to neutralization by their maternal plasma compared to contemporaneous maternal viruses. However, the newly transmitted variants were sensitive to neutralization by pooled heterologous plasma but in general were resistant to IgG1 b12. Neither Env processing nor incorporation efficiency was predictive of viral transmissibility. These findings provide further insight into the characteristics of perinatally transmissible HIV-1 and may have implications for intervention approaches. © 2009 Elsevier Inc.
Authors & Co-Authors
Zhang, Hong Y.
United States, Lincoln
University of Nebraska–lincoln
United States, Lincoln
School of Biological Sciences
Rola, Marzena
United States, Lincoln
University of Nebraska–lincoln
United States, Lincoln
School of Biological Sciences
West, John T.
United States, Oklahoma City
University of Oklahoma Health Sciences Center
Tully, Damien C.
United States, Lincoln
University of Nebraska–lincoln
United States, Lincoln
School of Biological Sciences
Kubis, Piotr
United States, Lincoln
University of Nebraska–lincoln
United States, Lincoln
School of Biological Sciences
He, Jun
United States, Lincoln
University of Nebraska–lincoln
United States, Lincoln
School of Biological Sciences
Kankasa, Chipepo
Zambia, Lusaka
University Teaching Hospital Lusaka
Wood, Charles
United States, Lincoln
University of Nebraska–lincoln
United States, Lincoln
School of Biological Sciences
Statistics
Citations: 52
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.virol.2009.12.019
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial