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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Genotypic and phenotypic characterization of human immunodeficiency virus type 1 isolates circulating in pregnant women from Mozambique
Archives of Virology, Volume 153, No. 11, Year 2008
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Description
This work evaluated HIV-1 subtypes from different geographic regions and phenotypic data from drug-naïve HIV-positive pregnant women from Mozambique. We analyzed 75 pol sequences from patients and the distribution of the subtypes in three regions of Mozambique and found that the majority of samples analyzed clustered with subtype C. In the northern region, multiple variants were found 5 (~18%) subtype A, 3 (~11%) subtype D and 2 (~7.1%) mosaics (A/C/D and C/D), whereas 18 (64.3%) isolates were subtype C, from a total of 28 samples. Already in the southern region, only one (5%) isolate of 20 samples was subtype D, and the other 19 (95%) isolates were subtype C. All 27 (100%) isolates from the central region grouped within clade C. No primary resistance mutations to IP, NNRTI or NRTI were found. There was no evidence of phenotypic resistance in any of the isolates tested, suggesting that neither the polymorphism in the protease, nor the one found at codon 215 of the RT gene caused an increase in phenotypic resistance. This finding suggests that HAART regimens indicated by WHO will probably be successful in Mozambique. © 2008 Springer-Verlag.
Authors & Co-Authors
Abreu, Celina Monteiro
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Brindeiro, Patrícia A.
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Martins, Angélica N.
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Arruda, M.
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Bule, E.
Mozambique, Maputo
Departamento de Saude Mental
Stakteas, Sergio
Mozambique, Maputo
Departamento de Saude Mental
Tanuri, Amílcar
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
De Moraes Brindeiro, Rodrigo
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Statistics
Citations: 23
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1007/s00705-008-0215-6
ISSN:
03048608
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Mozambique
Participants Gender
Female