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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Roflumilast, a phosphodiesterase 4 inhibitor, reduces airway hyperresponsiveness after allergen challenge
Respiration, Volume 74, No. 4, Year 2007
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Description
Background: Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, is currently in clinical development for the treatment of asthma. Objectives: This pilot study examined the effect of roflumilast on allergen-induced airway hyperresponsiveness (AHR) to histamine challenge and asthmatic response to allergen challenge. Methods: In a randomized, double-blind, 2-period, crossover trial, 13 patients with mild allergic asthma [mean forced expiratory volume in 1 s (FEV1) % predicted = 86%] received a single dose of oral roflumilast 1,000 μg or placebo. Patients were administered roflumilast 60 min before allergen challenge, and asthmatic responses were assessed via change in FEV1 ≤9 h after allergen challenge. AHR to histamine provocation was measured before and repeated 24 h after allergen provocation. Patients inhaled histamine in doubling concentrations until attaining a decrease in FEV1 of ≤20% (PC20FEV1). Results: Roflumilast had no detectable bronchodilator activity 60 min after administration. Roflumilast significantly attenuated AHR compared with placebo, with a mean change in pre- to postallergen challenge PC20FEV 1 ratio of 1.23 ± 2.75 and 2.51 ± 2.95 for roflumilast and placebo, respectively (p = 0.002). During the late asthmatic response, roflumilast reduced the mean maximum decrease in FEV1 from 2 to 9 h after allergen challenge compared with placebo (p = 0.005). Additionally, FEV1 at 9 h after challenge was significantly higher in patients treated with roflumilast (p = 0.03). Early asthmatic responses to allergen challenge were not significantly reduced by the single dose of roflumilast. Conclusions: Roflumilast attenuated allergen-induced AHR in patients with mild asthma. These results support further investigation of roflumilast as an anti-inflammatory treatment of asthma. Copyright © 2006 S. Karger AG.
Authors & Co-Authors
Louw, C.
South Africa, Stellenbosch
Stellenbosch University
Williams, Zelda
South Africa, Stellenbosch
Stellenbosch University
Venter, L.
South Africa
Altana Madaus (pty.) Ltd.
Leichtl, S.
Norway
Nycomed
Schmid-Wirlitsch, C.
Norway
Nycomed
Bredenbröker, D.
Norway
Nycomed
Bardin, Philip G.
Australia, Clayton
Faculty of Medicine, Nursing and Health Sciences
Australia, Clayton
Monash Medical Centre
Statistics
Citations: 44
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1159/000095677
ISSN:
00257931
Research Areas
Disability
Health System And Policy