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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Angiopoietin-2 serum levels correlate with severity, early onset and cardiovascular disease in patients with rheumatoid arthritis
Clinical and Experimental Rheumatology, Volume 31, No. 5, Year 2013
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Description
Objectives Rheumatoid arthritis (RA) is an inflammatory disease associated with accelerated atherosclerosis and high risk of cardiovascular (CV) disease. Angiopoietin-2 (Angpt-2), a marker of endothelial cell activation, has been proposed as a mediator of angiogenesis, which might play an important role in the regulation of endothelial integrity and inflammation. Therefore, the aim of this study was to determine whether Angpt-2 is related to severity and CV disease in RA patients. Methods Angpt-2 serum levels were measured by enzyme linked immunosorbent assay (ELISA) in 290 patients with RA. A control group of 100 individuals frequency matched by age and sex and classic CV risk factors and CV disease was also assessed. Results Eighty-four patients with RA (28.9%) had experienced CV events. Also, extra-articular manifestations were present in 41 (14%) of these patients. Although there were not significant differences between patients and controls, a correlation between age at the time of disease onset and Angpt-2 was observed in RA patients (r=-0.31; p=0.02). Angpt-2 serum levels also correlated positively with extra-articular disease (mean±standard deviation in RA patients with and without extra-articular manifestations were 2476±1716 pg/ml and 1897±1228 pg/ml, respectively; p=0.01). Moreover, after adjustment for sex, age at RA diagnosis and CV risk factors, Angpt-2 levels were higher in RA patients with CV disease than in RA patients without CV complications (2472±1826 pg/ml vs. 1875±1101 pg/ml; p=0.05). Angpt-2 serum levels remained significantly higher in RA patients with CV disease compared to those without CV disease after additional adjustment for extra-articular manifestations (p=0.04). Conclusion Our results show that Angpt-2 serum levels correlate with disease severity, early onset and CV disease in RA patients. © Clinical and Experimental Rheumatology 2013.
Authors & Co-Authors
López-Mejías, Raquel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Corrales, Alfonso F.
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Genre, Fernanda
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Herńandez, José L.
Spain, Santander
Universidad de Cantabria
Blanco-Alonso, Ricardo
Spain, Santander
Hospital Universitario Marqués de Valdecilla
González-Juanatey, Carlos
Spain, Lugo
Hospital Lucus Augusti
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Llorca-Díaz, Javier Francisco
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
González-Gay, Miguel Ángel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Statistics
Citations: 32
Authors: 9
Affiliations: 5
Identifiers
ISSN:
1593098X
Research Areas
Cancer
Noncommunicable Diseases
Study Design
Randomised Control Trial