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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells
Breast Cancer Research and Treatment, Volume 137, No. 3, Year 2013
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Description
Since epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and in maintaining cancer stem cell properties, EMT is emerging as a therapeutic target for inhibiting the metastatic progression of cancer cells. 2′-Hydroxycinnamaldehyde (HCA) and its derivative, 2′-benzoyloxycinnamaldehyde, have recently been suggested as promising therapeutic candidates for cancer treatment. The purpose of this study is to investigate the anti-metastatic effect of HCA on breast cancer and the molecular mechanisms by which HCA regulates the transcriptional program during EMT. HCA induces epithelial reversion at nanomolar concentrations by suppressing Snail via the nuclear translocalization of GSK-3β, which results in the transcriptional upregulation of E-cadherin. HCA also activates the transcription factor KLF17, which suppresses Id-1, indicating that HCA inhibits EMT by multiple transcriptional programs. Further, HCA treatment significantly inhibits lung metastasis in a mouse orthotopic breast cancer model. This study demonstrates the anti-metastatic effect of the non-toxic natural compound HCA through attenuation of EMT in a breast cancer model. © 2012 Springer Science+Business Media New York.
Authors & Co-Authors
Ismail, Ismail A.
South Korea, Daegu
Kyungpook National University
Egypt, Asyut
Faculty of Science
Kang, Hye-sook
South Korea, Daegu
Kyungpook National University
Lee, Heon Jin
South Korea, Daegu
Kyungpook National University
Chang, Hyeyoun
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Yun, Jieun
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Lee, Changwoo
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Kim, Namhee
South Korea, Seoul
Yonsei University College of Dentistry
Kim, Hyun-sil
South Korea, Seoul
Yonsei University College of Dentistry
Yook, Jongin
South Korea, Seoul
Yonsei University College of Dentistry
Hong, Suhyung
South Korea, Daegu
Kyungpook National University
Kwon, Byoung-mog
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Statistics
Citations: 30
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1007/s10549-012-2388-7
ISSN:
01676806
e-ISSN:
15737217
Research Areas
Cancer
Environmental