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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Multi-analyte profiling of ten cytokines in South African HIV-infected patients with Immune Reconstitution Inflammatory Syndrome (IRIS)
AIDS Research and Therapy, Volume 7, Article 36, Year 2010
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Description
Background: Immune reconstitution inflammatory syndrome (IRIS) is an important complication of HAART in sub-Saharan Africa, where opportunistic infections (OIs) including mycobacteria and cryptococcus are common. The immune system's role in HIV infected patients is complex with cytokine expression strongly influencing HIV infection and replication.Methods: We determined the expression patterns of 10 cytokines by Luminex multi-analyte profiling in 17 IRIS nested case-control pairs participating in a prospective South African cohort initiating anti-retroviral therapy.Results: Interferon-gamma (IFN-γ) expression was significantly elevated in IRIS cases compared to controls (median 9.88 pg/ml versus 2.68 pg/ml, respectively, P = 0.0057), while other cytokines displayed non-significant differences in expression. Significant correlation was observed between IL-6, IL-10, and IFN-γ expression in the IRIS patients.Conclusions: Significantly increased expression levels of IFN-γ suggest that this cytokine possibly plays a role in IRIS pathology and is a potential diagnostic marker. © 2010 Worsley et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Worsley, Catherine M.
South Africa, Johannesburg
National Health Laboratory Service
Suchard, Melinda Shelley
South Africa, Johannesburg
National Health Laboratory Service
Stevens, Wendy Susan
South Africa, Johannesburg
National Health Laboratory Service
van Rie, Annelies
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Murdoch, David M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Durham
Duke University Medical Center
Statistics
Citations: 42
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1186/1742-6405-7-36
ISSN:
17426405
Research Areas
Infectious Diseases
Study Design
Cohort Study
Case-Control Study