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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Identification of a high diversity of Cryptosporidium species genotypes and subtypes in a pediatric population in Nigeria
American Journal of Tropical Medicine and Hygiene, Volume 82, No. 4, Year 2010
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Description
A longitudinal study was conducted to determine the epidemiology of Cryptosporidium in 1,636 children in Nigeria. Oocyst prevalence ranged from 15.6% to 19.6% over one year. Cryptosporidium hominis (34), C. parvum (25), C. parvum/C. hominis (4), C. meleagridis (5), Cryptosporidium rabbit genotype (5), Cryptosporidium cervine genotype (3), and C. canis (1) were identified by polymerase chain reaction-restriction fragment length polymorphism analysis. Glycoprotein 60 subgenotyping showed that 28 amplifiable C. hominis isolates consisted of 12 subtypes that belonged to 5 subtype families (Ia, Ib, Id, Ie, and 1 novel subtype family, Ih) and 23 amplifiable C. parvum isolates consisted of 6 subtypes that belonged to 4 subtype families (IIa, IIc, Iii, and IIm). Three C. meleagridis isolates sub-genotyped by sequence analysis of the small subunit ribosomal RNA gene fragment were type 1. This study is the first one to genetically characterize Cryptosporidium species and subtypes in Nigeria and highlights the presence of a high Cryptosporidium diversity in this pediatric population. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Molloy, Síle F.
Ireland, Dublin
Trinity College Dublin
Smith, Huw Vaughan
United Kingdom, Glasgow
New Stobhill Hospital
Kirwan, Patrick
Ireland, Dublin
Trinity College Dublin
Nichols, Rosely Angela Bergamin
United Kingdom, Glasgow
New Stobhill Hospital
Asaolu, Samuel O.
Nigeria, Ife
Obafemi Awolowo University
Connelly, L.
United Kingdom, Glasgow
New Stobhill Hospital
Holland, Celia V.
Ireland, Dublin
Trinity College Dublin
Statistics
Citations: 101
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2010.09-0624
ISSN:
00029637
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Nigeria