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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Accuracy and reliability of malaria diagnostic techniques for guiding febrile outpatient treatment in malaria-endemic countries
American Journal of Tropical Medicine and Hygiene, Volume 78, No. 2, Year 2008
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Description
The main purpose of this study was to assess the accuracy of various techniques available for diagnosis of malaria. Blood samples were collected from 313 patients with clinical suspicion of uncomplicated malaria in 2 primary health centers in Madagascar. The presence of Plasmodium parasites was assessed by conventional microscopy, 2 rapid diagnostic tests (one HRP2-based test, PALUTOP+4, and one pLDH-based test, OptiMAL-IT), and real-time polymerase chain reaction (PCR), which is used as the "gold standard" method. The degree of agreement observed was very high for microscopy (0.99) and the HRP2-based test (0.93) and high for the pLDH-based test (0.82). Public-health implications are also discussed in this paper. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Rakotonirina, Hanitra Clara
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Barnadas, Céline
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Raherijafy, Rogelin
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Andrianantenaina, Herilalaina B.
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ratsimbasoa, Arsène C.
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Randrianasolo, Laurence
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Jahevitra, Martial
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Andriantsoanirina, Valérie
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ménard, Didier
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Statistics
Citations: 86
Authors: 9
Affiliations: 1
Identifiers
Doi:
10.4269/ajtmh.2008.78.217
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Madagascar