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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter-gatherers and Bantu-speaking farmers
Proceedings of the National Academy of Sciences of the United States of America, Volume 105, No. 5, Year 2008
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Description
Two groups of populations with completely different life-styles - the Pygmy hunter- gatherers and the Bantu-speaking farmers - coexist in Central Africa. We investigated the origins of these two groups and the interactions between them, by analyzing mtDNA variation in 1,404 individuals from 20 farming populations and 9 Pygmy populations from Central Africa, with the aim of shedding light on one of the most fascinating cultural transitions in human evolution (the transition from hunting and gathering to agriculture). Our data indicate that this region was colonized gradually, with an initial L1c-rich ancestral population ultimately giving rise to current-day farmers, who display various L1c clades, and to Pygmies, in whom L1c1a is the only surviving clade. Detailed phylogenetic analysis of complete mtDNA sequences for L1c1a showed this clade to be autochthonous to Central Africa, with its most recent branches shared between farmers and Pygmies. Coalescence analyses revealed that these two groups arose through a complex evolutionary process characterized by (i) initial divergence of the ancestors of contemporary Pygmies from an ancestral Central African population no more than ≈70,000 years ago, (ii) a period of isolation between the two groups, accounting for their phenotypic differences, (iii) long-standing asymmetric maternal gene flow from Pygmies to the ancestors of the farming populations, beginning no more than ≈40,000 years ago and persisting until a few thousand years ago, and (iv) enrichment of the maternal gene pool of the ancestors of the farming populations by the arrival and/or subsequent demographic expansion of L0a, L2, and L3 carriers. © 2008 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2234190/bin/pnas_0711467105_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2234190/bin/pnas_0711467105_1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2234190/bin/pnas_0711467105_11467Table3.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2234190/bin/pnas_0711467105_2.pdf
Authors & Co-Authors
Quintana-Murci, Lluís
France, Paris
Cnrs Centre National de la Recherche Scientifique
Quach, Hélène
France, Paris
Cnrs Centre National de la Recherche Scientifique
Harmant, Christine
France, Paris
Cnrs Centre National de la Recherche Scientifique
Luca, Francesca
France, Paris
Cnrs Centre National de la Recherche Scientifique
Massonnet, Blandine
France, Paris
Cnrs Centre National de la Recherche Scientifique
Patin, Etienne
France, Paris
Cnrs Centre National de la Recherche Scientifique
Sica, Lucas
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Mouguiama-Daouda, Patrick
France, Lyon
Maison Des Sciences de l' Homme Lyon St-étienne
Comas, D.
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Tzur, Shay
Israel, Haifa
Molecular Medicine Laboratory
Balanovsky, Oleg P.
Russian Federation, Moscow
Russian Academy of Medical Sciences
Kidd, Kenneth K.
United States, New Haven
Yale School of Medicine
Kidd, Judith R.
United States, New Haven
Yale School of Medicine
Van Der Veen, Lolke
France, Lyon
Maison Des Sciences de l' Homme Lyon St-étienne
Hombert, Jean Marie
France, Lyon
Maison Des Sciences de l' Homme Lyon St-étienne
Gessain, Antoine
France, Paris
Institut Pasteur, Paris
Verdu, Paul
France, Paris
Museé de L'homme
Froment, Alain
France, Paris
Museé de L'homme
Bahuchet, Serge
France, Paris
Museé de L'homme
Heyer, Evelyne
France, Paris
Museé de L'homme
Dausset, Jean B.
France, Paris
Fondation Jean Dausset - Ceph
Salas, Antonio
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Behar, Doron M.
Israel, Haifa
Molecular Medicine Laboratory
Statistics
Citations: 196
Authors: 23
Affiliations: 11
Identifiers
Doi:
10.1073/pnas.0711467105
ISSN:
00278424
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study