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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Slow freezing, vitrification and ultra-rapid freezing of human embryos: A systematic review and meta-analysis
Reproductive BioMedicine Online, Volume 20, No. 2, Year 2010
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Description
Embryo cryopreservation is an important aspect of assisted reproduction. Many methods have been described, but they have been poorly investigated in randomized trials, highlighting the need for a systematic review of the literature. Meticulous electronic/hand searches were performed to locate randomized trials (RCT) comparing embryo cryopreservation methods. Primary outcomes were clinical pregnancy rate (CPR) and incidence of congenital abnormalities. Secondary outcomes included live-birth (LBR), ongoing pregnancy (OPR), implantation (IR), and miscarriage (MR) rates. Data were extracted to allow for an intention-to-treat analysis and analysed using a random-effects model. Literature search revealed 11 RCT, of which five were excluded. The quality of the included studies was variable, but generally poor. There was a significantly higher CPR, OPR and IR with vitrification compared with slow freezing (odds ratio (OR) = 1.55, 95% confidence interval (Cl) = 1.03-2.32, OR= 1.82, 95% Cl = 1.04-3.20 and OR = 1.49, 95% Cl = 1.03-2.15, respectively). In addition, there was a significantly lower CPR and OPR with embryo ultra-rapid freezing compared with slow freezing (OR = 0.35, 95% Cl = 0.16-0.76 and OR = 0.37, 95% Cl = 0.17-0.81, respectively). Vitrification is superior to slow freezing, which in turn is superior to ultra-rapid freezing. However, more well-designed and powered studies are needed to further corroborate these findings. © 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Authors & Co-Authors
AbdelHafez, Faten F.
United States, Cleveland
Cleveland Clinic Foundation
Desai, Nina
United States, Cleveland
Cleveland Clinic Foundation
Abou-Setta, Ahmed M.
Egypt, Giza
Private Clinic
Canada, Edmonton
Alberta Research Centre for Health Evidence
Falcone, Tommaso
United States, Cleveland
Cleveland Clinic Foundation
Goldfarb, James
United States, Cleveland
Cleveland Clinic Foundation
Statistics
Citations: 213
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.rbmo.2009.11.013
ISSN:
14726483
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Case-Control Study
Study Approach
Quantitative
Systematic review